ENSMUSG00000020592


Mus musculus

Features
Gene ID: ENSMUSG00000020592
  
Biological name :Sdc1
  
Synonyms : P18828 / Sdc1 / syndecan 1
  
Possible biological names infered from orthology : P18827
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 8771323
Gene end: 8793715
  
Corresponding Affymetrix probe sets: 10394471 (MoGene1.0st)   1415943_at (Mouse Genome 430 2.0 Array)   1415944_at (Mouse Genome 430 2.0 Array)   1437279_x_at (Mouse Genome 430 2.0 Array)   1448158_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020911
Ensembl peptide - ENSMUSP00000123896
Ensembl peptide - ENSMUSP00000131491
NCBI entrez gene - 20969     See in Manteia.
MGI - MGI:1349162
RefSeq - XM_006515046
RefSeq - NM_011519
RefSeq - XM_006515045
RefSeq Peptide - NP_035649
swissprot - P18828
swissprot - Q3V1F2
swissprot - E0CYT6
Ensembl - ENSMUSG00000020592
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SDC1ENSGALG00000016480Gallus gallus
 SDC1ENSG00000115884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sdc3 / Q64519 / syndecan 3 / O75056*ENSMUSG0000002574334
Sdc2 / P43407 / Syndecan-2 / P34741*ENSMUSG0000002226122
Sdc4 / O35988 / syndecan 4 / P31431*ENSMUSG0000001700918


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031190  Syndecan-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0048627 myoblast development IDA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055002 striated muscle cell development IEA
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:1903543 positive regulation of exosomal secretion ISO
 biological_processGO:1903553 positive regulation of extracellular exosome assembly ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Other interleukin signaling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Prop1df/Prop1df
Genetic Background: involves: C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prop1df/Prop1df
Genetic Background: involves: C57BL/6J

Allelic Composition: Sdc1tm1Cma/Sdc1+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi
Genetic Background: Not Specified

Allelic Composition: Sdc1tm1Cma/Sdc1tm1Cma
Genetic Background: B6.Cg-Sdc1tm1Cma

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Sgk3tm1Dpea/Sgk3tm1Dpea
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Serpine2tm1Dmn/Serpine2tm1Dmn,Tg(Thy1-Serpine2)2Dmn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sdc1tm1Cma/Sdc1tm1Cma
Genetic Background: B6.Cg-Sdc1tm1Cma

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024621 Csf1r / P09581 / Macrophage colony-stimulating factor 1 receptor / P07333* / colony stimulating factor 1 receptor*  / complex
 ENSMUSG00000031750 Il34 / Q8R1R4 / Interleukin-34 / Q6ZMJ4*  / complex / reaction






 

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