ENSG00000115884


Homo sapiens

Features
Gene ID: ENSG00000115884
  
Biological name :SDC1
  
Synonyms : P18827 / SDC1 / syndecan 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p24.1
Gene start: 20200797
Gene end: 20225433
  
Corresponding Affymetrix probe sets: 201286_at (Human Genome U133 Plus 2.0 Array)   201287_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254351
Ensembl peptide - ENSP00000384613
Ensembl peptide - ENSP00000390201
Ensembl peptide - ENSP00000400773
Ensembl peptide - ENSP00000370542
NCBI entrez gene - 6382     See in Manteia.
OMIM - 186355
RefSeq - XM_005262622
RefSeq - NM_001006946
RefSeq - NM_002997
RefSeq - XM_005262620
RefSeq - XM_005262621
RefSeq Peptide - NP_001006947
RefSeq Peptide - NP_002988
swissprot - F8WCX9
swissprot - H7C1K4
swissprot - P18827
swissprot - E9PHH3
Ensembl - ENSG00000115884
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SDC1ENSGALG00000016480Gallus gallus
 Sdc1ENSMUSG00000020592Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SDC3 / O75056 / syndecan 3ENSG0000016251235
SDC2 / P34741 / syndecan 2ENSG0000016943922
SDC4 / P31431 / syndecan 4ENSG0000012414519


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031190  Syndecan-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0048627 myoblast development IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0055002 striated muscle cell development IEP
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903553 positive regulation of extracellular exosome assembly IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Other interleukin signaling
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157368 IL34 / Q6ZMJ4 / interleukin 34  / reaction / complex
 ENSG00000182578 CSF1R / P07333 / colony stimulating factor 1 receptor  / complex






 

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