ENSG00000162512


Homo sapiens

Features
Gene ID: ENSG00000162512
  
Biological name :SDC3
  
Synonyms : O75056 / SDC3 / syndecan 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.2
Gene start: 30869467
Gene end: 30908761
  
Corresponding Affymetrix probe sets: 1554864_a_at (Human Genome U133 Plus 2.0 Array)   202898_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000344468
Ensembl peptide - ENSP00000338346
NCBI entrez gene - 9672     See in Manteia.
OMIM - 186357
RefSeq - XM_011542466
RefSeq - NM_014654
RefSeq - XM_011542463
RefSeq - XM_011542464
RefSeq Peptide - NP_055469
swissprot - D3DPN2
swissprot - O75056
Ensembl - ENSG00000162512
  
Related genetic diseases (OMIM): 601665 - {Obesity, association with}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SDC3ENSGALG00000035184Gallus gallus
 Sdc3ENSMUSG00000025743Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SDC1 / P18827 / syndecan 1ENSG0000011588424
SDC4 / P31431 / syndecan 4ENSG0000012414517
SDC2 / P34741 / syndecan 2ENSG0000016943917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031194  Syndecan-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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