ENSG00000124145


Homo sapiens

Features
Gene ID: ENSG00000124145
  
Biological name :SDC4
  
Synonyms : P31431 / SDC4 / syndecan 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.12
Gene start: 45325288
Gene end: 45348424
  
Corresponding Affymetrix probe sets: 202071_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361818
NCBI entrez gene - 6385     See in Manteia.
OMIM - 600017
RefSeq - NM_002999
RefSeq - XM_011528977
RefSeq Peptide - NP_002990
swissprot - P31431
Ensembl - ENSG00000124145
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdc4ENSDARG00000059906Danio rerio
 SDC4ENSGALG00000003932Gallus gallus
 Sdc4ENSMUSG00000017009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SDC3 / O75056 / syndecan 3ENSG0000016251239
SDC2 / P34741 / syndecan 2ENSG0000016943936
SDC1 / P18827 / syndecan 1ENSG0000011588429


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IMP
 biological_processGO:1903553 positive regulation of extracellular exosome assembly IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0070053 thrombospondin receptor activity IMP


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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