ENSMUSG00000017009


Mus musculus

Features
Gene ID: ENSMUSG00000017009
  
Biological name :Sdc4
  
Synonyms : O35988 / Sdc4 / syndecan 4
  
Possible biological names infered from orthology : P31431
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 164424247
Gene end: 164443887
  
Corresponding Affymetrix probe sets: 10489484 (MoGene1.0st)   1417654_at (Mouse Genome 430 2.0 Array)   1448793_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017153
NCBI entrez gene - 20971     See in Manteia.
MGI - MGI:1349164
RefSeq - NM_011521
RefSeq Peptide - NP_035651
swissprot - O35988
swissprot - Q3U5S6
Ensembl - ENSMUSG00000017009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdc4ENSDARG00000059906Danio rerio
 SDC4ENSGALG00000003932Gallus gallus
 SDC4ENSG00000124145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sdc3 / Q64519 / syndecan 3 / O75056*ENSMUSG0000002574340
Sdc2 / P43407 / Syndecan-2 / P34741*ENSMUSG0000002226137
Sdc1 / P18828 / syndecan 1 / P18827*ENSMUSG0000002059228


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001843 neural tube closure IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0042060 wound healing IGI
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IGI
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 biological_processGO:1903553 positive regulation of extracellular exosome assembly IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043034 costamere IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0070053 thrombospondin receptor activity IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010238 increased skeletal muscle weight "greater than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011333 abnormal kidney inner medulla morphology "any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle" [MGI:csmith, PMID:20614633]
Show

Allelic Composition: Fgfr2tm1Dor/Fgfr2tm1Dor,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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