ENSMUSG00000025743


Mus musculus

Features
Gene ID: ENSMUSG00000025743
  
Biological name :Sdc3
  
Synonyms : Q64519 / Sdc3 / syndecan 3
  
Possible biological names infered from orthology : O75056
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 130792537
Gene end: 130826319
  
Corresponding Affymetrix probe sets: 10508651 (MoGene1.0st)   1420853_at (Mouse Genome 430 2.0 Array)   1436482_a_at (Mouse Genome 430 2.0 Array)   1450027_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065877
Ensembl peptide - ENSMUSP00000118685
Ensembl peptide - ENSMUSP00000123608
NCBI entrez gene - 20970     See in Manteia.
MGI - MGI:1349163
RefSeq - XM_017320091
RefSeq - NM_011520
RefSeq - XM_006538688
RefSeq - XM_017320090
RefSeq Peptide - NP_035650
swissprot - B1ASF6
swissprot - Q64519
Ensembl - ENSMUSG00000025743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SDC3ENSGALG00000035184Gallus gallus
 SDC3ENSG00000162512Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sdc1 / P18828 / syndecan 1 / P18827*ENSMUSG0000002059224
Sdc4 / O35988 / syndecan 4 / P31431*ENSMUSG0000001700918
Sdc2 / P43407 / Syndecan-2 / P34741*ENSMUSG0000002226118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031194  Syndecan-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016477 cell migration IBA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Tg(Tbx1-cre)1Joe/0
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sdc3tm1Rau/Sdc3+
Genetic Background: B6.129S-Sdc3tm1Rau

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sdc3tm1Rau/Sdc3+
Genetic Background: B6.129S-Sdc3tm1Rau

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr2tm1Gar/Npr2tm1Gar
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr