ENSMUSG00000028364


Mus musculus

Features
Gene ID: ENSMUSG00000028364
  
Biological name :Tnc
  
Synonyms : Q80YX1 / tenascin C / Tnc
  
Possible biological names infered from orthology : P24821
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C1
Gene start: 63959785
Gene end: 64047015
  
Corresponding Affymetrix probe sets: 10513739 (MoGene1.0st)   1416342_at (Mouse Genome 430 2.0 Array)   1456344_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030056
Ensembl peptide - ENSMUSP00000102994
Ensembl peptide - ENSMUSP00000102995
Ensembl peptide - ENSMUSP00000103000
NCBI entrez gene - 21923     See in Manteia.
MGI - MGI:101922
RefSeq - XM_006537777
RefSeq - NM_011607
RefSeq - XM_006537774
RefSeq - XM_006537775
RefSeq - XM_006537776
RefSeq Peptide - NP_035737
swissprot - Q80YX0
swissprot - Q80YX1
Ensembl - ENSMUSG00000028364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tncENSDARG00000021948Danio rerio
 zmp:0000000846ENSDARG00000078362Danio rerio
 TNCENSGALG00000039990Gallus gallus
 TNCENSG00000041982Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnxb / tenascin XB / P22105*ENSMUSG0000003332735
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582929
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672525
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619319
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG000000280018
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG000000338316
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG000000315945
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG000000285535
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG000000022895
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG000000338605


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR033078  Tenascin-C
 IPR036056  Fibrinogen-like, C-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014012 peripheral nervous system axon regeneration IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0060447 bud outgrowth involved in lung branching IEA
 biological_processGO:0060739 mesenchymal-epithelial cell signaling involved in prostate gland development IMP
 biological_processGO:0060740 prostate gland epithelium morphogenesis IMP
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 biological_processGO:0071799 cellular response to prostaglandin D stimulus IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0001968 fibronectin binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045545 syndecan binding IEA


Pathways (from Reactome)
Pathway description
Integrin cell surface interactions
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Htttm3Szi/Htt+
Genetic Background: involves: 129S1/Sv

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htttm3Szi/Htt+
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm2.1Alj
Genetic Background: either: (involves: 129) or (involves: 129 * Black Swiss)

Allelic Composition: Tnctm1Sia/Tnctm1Sia
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn
Genetic Background: B6.129S2-Ighmtm1Cgn/J

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Hif1atm2Rsjo/Hif1atm2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex / reaction
 ENSMUSG00000025743 Sdc3 / Q64519 / syndecan 3 / O75056*  / complex / reaction
 ENSMUSG00000039115 Itga9 / B8JK39 / Integrin alpha-9 / Q13797* / integrin subunit alpha 9*  / reaction / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / complex
 ENSMUSG00000026768 Itga8 / A2ARA8 / Integrin alpha-8 Integrin alpha-8 heavy chain Integrin alpha-8 light chain / P53708* / integrin subunit alpha 8*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / complex / reaction






 

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