ENSMUSG00000028553


Mus musculus

Features
Gene ID: ENSMUSG00000028553
  
Biological name :Angptl3
  
Synonyms : Angiopoietin-related protein 3 ANGPTL3(17-224) / Angptl3 / Q9R182
  
Possible biological names infered from orthology : angiopoietin like 3 / Q9Y5C1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 99030954
Gene end: 99046111
  
Corresponding Affymetrix probe sets: 10506125 (MoGene1.0st)   1424485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030280
NCBI entrez gene - 30924     See in Manteia.
MGI - MGI:1353627
RefSeq - NM_013913
RefSeq Peptide - NP_038941
swissprot - Q3UEF5
swissprot - Q9R182
Ensembl - ENSMUSG00000028553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angptl3ENSDARG00000044365Danio rerio
 ANGPTL3ENSGALG00000010978Gallus gallus
 Q9Y5C1ENSG00000132855Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG0000000228928
Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*ENSMUSG0000002800124
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582923
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG0000003386023
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836423
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672522
Tnxb / tenascin XB / P22105*ENSMUSG0000003332721
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG0000003383120
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG0000003159420
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619317


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006071 glycerol metabolic process ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process NAS
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010519 negative regulation of phospholipase activity ISO
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045834 positive regulation of lipid metabolic process NAS
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0050996 positive regulation of lipid catabolic process IEA
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity ISO
 biological_processGO:0055088 lipid homeostasis IEA
 biological_processGO:0055090 acylglycerol homeostasis IMP
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IDA
 molecular_functionGO:0004859 phospholipase inhibitor activity ISO
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr3tm1Unc/Npr3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Angptl3tm1Kfuj/Angptl3tm1Kfuj
Genetic Background: B6.129S1-Angptl3tm1Kfuj

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos,Angptl4tm1Akos/Angptl4tm1Akos
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011578 increased lipoprotein lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
Show

Allelic Composition: Nodaltm1Hmd/Nodal+,Tg(Leftb)1Hmd/0
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)

Allelic Composition: Angptl3tm1Akos/Angptl3tm1Akos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047822 Q8R1L8 / Angptl8 / Angiopoietin-like protein 8 / Q6UXH0* / angiopoietin like 8*  / reaction / complex






 

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