ENSMUSG00000047822


Mus musculus

Features
Gene ID: ENSMUSG00000047822
  
Biological name :Angptl8
  
Synonyms : Angiopoietin-like protein 8 / Angptl8 / Q8R1L8
  
Possible biological names infered from orthology : angiopoietin like 8 / Q6UXH0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 21835510
Gene end: 21837347
  
Corresponding Affymetrix probe sets: 10583753 (MoGene1.0st)   1427422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058951
NCBI entrez gene - 624219     See in Manteia.
MGI - MGI:3643534
RefSeq - NM_001080940
RefSeq Peptide - NP_001074409
swissprot - A0A0A0R784
swissprot - Q8R1L8
Ensembl - ENSMUSG00000047822
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6UXH0ENSG00000130173Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026614  Angiopoietin-like protein 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010954 positive regulation of protein processing ISO
 biological_processGO:0019216 regulation of lipid metabolic process ISO
 biological_processGO:0044255 cellular lipid metabolic process TAS
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0050746 regulation of lipoprotein metabolic process IMP
 biological_processGO:0051005 negative regulation of lipoprotein lipase activity TAS
 biological_processGO:0070328 triglyceride homeostasis TAS
 cellular_componentGO:0005576 extracellular region ISO
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8+
Genetic Background: involves: C57BL/6NTac

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0011578 increased lipoprotein lipase activity "greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
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Allelic Composition: Angptl8tm1(KOMP)Vlcg/Angptl8tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028553 Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*  / reaction / complex






 

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