ENSMUSG00000020689


Mus musculus

Features
Gene ID: ENSMUSG00000020689
  
Biological name :Itgb3
  
Synonyms : Integrin beta-3 / Itgb3 / O54890
  
Possible biological names infered from orthology : AC068234.1 / integrin subunit beta 3 / P05106
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 104608000
Gene end: 104670476
  
Corresponding Affymetrix probe sets: 10381809 (MoGene1.0st)   1421511_at (Mouse Genome 430 2.0 Array)   1455257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021028
NCBI entrez gene - 16416     See in Manteia.
MGI - MGI:96612
RefSeq - NM_016780
RefSeq - XM_006532312
RefSeq Peptide - NP_058060
swissprot - O54890
Ensembl - ENSMUSG00000020689
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itgb3aENSDARG00000056767Danio rerio
 itgb3bENSDARG00000045070Danio rerio
 ITGB3ENSGALG00000000379Gallus gallus
 AC068234.1ENSG00000259753Homo sapiens
 ITGB3ENSG00000259207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itgb5 / integrin subunit beta 5 / P18084*ENSMUSG0000002281753
Itgb6 / Q9Z0T9 / Integrin beta-6 / P18564* / integrin subunit beta 6*ENSMUSG0000002697149
Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*ENSMUSG0000002580943
Itgb2 / P05107* / integrin subunit beta 2*ENSMUSG0000000029038
Itgb7 / P26011 / Integrin beta-7 / P26010* / integrin subunit beta 7*ENSMUSG0000000128138
Itgb4 / A2A863 / Integrin beta-4 / P16144* / integrin subunit beta 4*ENSMUSG0000002075834
Itgb8 / integrin subunit beta 8 / P26012*ENSMUSG0000002532133
Itgb2l / Q3UV74 / Integrin beta-2-like protein / ITGB2* / P05107* / integrin subunit beta 2*ENSMUSG0000000015730
Itgbl1 / Q8VDV0 / Integrin beta-like protein 1 / O95965* / integrin subunit beta like 1*ENSMUSG0000003292516


Protein motifs (from Interpro)
Interpro ID Name
 IPR002369  Integrin beta subunit, VWA domain
 IPR012896  Integrin beta subunit, tail
 IPR013111  EGF-like domain, extracellular
 IPR014836  Integrin beta subunit, cytoplasmic domain
 IPR015812  Integrin beta subunit
 IPR016201  PSI domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027068  Integrin beta-3 subunit
 IPR032695  Integrin domain superfamily
 IPR033760  Integrin beta N-terminal
 IPR036349  Integrin beta tail domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily
 IPR037076  Integrin beta subunit, cytoplasmic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007044 cell-substrate junction assembly IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation ISO
 biological_processGO:0010763 positive regulation of fibroblast migration IMP
 biological_processGO:0010888 negative regulation of lipid storage ISO
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014909 smooth muscle cell migration ISO
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0030168 platelet activation ISO
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031589 cell-substrate adhesion ISO
 biological_processGO:0032147 activation of protein kinase activity ISO
 biological_processGO:0032369 negative regulation of lipid transport ISO
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0033627 cell adhesion mediated by integrin ISO
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0034113 heterotypic cell-cell adhesion ISO
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISO
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0036119 response to platelet-derived growth factor IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IMP
 biological_processGO:0038027 apolipoprotein A-I-mediated signaling pathway ISO
 biological_processGO:0043277 apoptotic cell clearance IGI
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IC
 biological_processGO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045780 positive regulation of bone resorption IC
 biological_processGO:0046718 viral entry into host cell ISO
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048858 cell projection morphogenesis IC
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050748 negative regulation of lipoprotein metabolic process ISO
 biological_processGO:0050919 negative chemotaxis ISO
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061097 regulation of protein tyrosine kinase activity IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1900731 positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
 biological_processGO:1903053 regulation of extracellular matrix organization IMP
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0008305 integrin complex ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031258 lamellipodium membrane ISO
 cellular_componentGO:0031527 filopodium membrane ISO
 cellular_componentGO:0031528 microvillus membrane ISO
 cellular_componentGO:0032587 ruffle membrane ISO
 cellular_componentGO:0034679 integrin alpha9-beta1 complex TAS
 cellular_componentGO:0034683 integrin alphav-beta3 complex ISO
 cellular_componentGO:0035866 alphav-beta3 integrin-PKCalpha complex IDA
 cellular_componentGO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex ISO
 cellular_componentGO:0035868 alphav-beta3 integrin-HMGB1 complex ISO
 cellular_componentGO:0042470 melanosome ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0071133 alpha9-beta1 integrin-ADAM8 complex IDA
 molecular_functionGO:0001968 fibronectin binding ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0003756 protein disulfide isomerase activity ISO
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017134 fibroblast growth factor binding ISO
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019960 C-X3-C chemokine binding ISO
 molecular_functionGO:0031994 insulin-like growth factor I binding ISO
 molecular_functionGO:0038132 neuregulin binding ISO
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding ISO
 molecular_functionGO:0050839 cell adhesion molecule binding ISO
 molecular_functionGO:0050840 extracellular matrix binding ISO
 molecular_functionGO:0070051 fibrinogen binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Elastic fibre formation
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
Signal transduction by L1
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd84tm1Pls/Cd84tm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Fbn1tm2.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fbn1tm3.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Fbn1tm2.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fbn1tm3.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Cd84tm1Pls/Cd84tm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb3tm1.1Wlbcr/Itgb3tm1.1Wlbcr
Genetic Background: involves: C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slco2a1tm1.2Vsch/Slco2a1tm1.2Vsch
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Cd84tm1Pls/Cd84tm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slco2a1tm1.2Vsch/Slco2a1tm1.2Vsch
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003946 renal necrosis "pathological cell death in the kidney, usually due to irreversible damage" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0004244 abnormal spontaneous abortion rate "change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cd84tm1Pls/Cd84tm1Pls,Tg(TcraTcrb)425Cbn/?
Genetic Background: B6.Cg-Cd84tm1Pls Tg(TcraTcrb)425Cbn

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm2Mgin/Itgb3tm2Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas * BALB/c

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1tm2.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fbn1tm3.1Hcd/Fbn1+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008837 increased transforming growth factor level "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ilktm2Star/Ilk+,Itgb3tm1Hyn/Itgb3+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Aja/Itgb3tm1Aja
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129S2/SvPas

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009676 abnormal hemostasis "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [MESH:G09.188.124.560, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1Hyn,Itgb5tm1Des/Itgb5tm1Des
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Itgb3tm1Hyn/Itgb3tm1Hyn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Itgb3tm1Mgin/Itgb3tm1Mgin
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011515 purpura "a smooth, moderately sized hemorrhagic area, typically dark red to reddish purple, resulting from extarvasation of blood into the skin, mucous membrane, or serosal surface; a pupura becomes brown-yellow as it fades and does not blanch on applying pressure" [MGI:anna]
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Allelic Composition: Hoxa1tm1Mrc/Hoxa1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
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Allelic Composition: Itgb3tm1Hyn/Itgb3tm1.1Wlbcr,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000031849 Comp / Q9R0G6 / Cartilage oligomeric matrix protein / P49747*  / complex / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000040152 Thbs1 / thrombospondin 1 / P07996*  / reaction / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000029307 Dmp1 / O55188 / Dentin matrix acidic phosphoprotein 1 / Q13316*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / complex / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / reaction / complex
 ENSMUSG00000028364 Tnc / Q80YX1 / tenascin C / P24821*  / reaction / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000044813 Shb / Q6PD21 / SH2 domain-containing adapter protein B / Q15464* / AL138752.2* / SH2 domain containing adaptor protein B*  / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000029306 Ibsp / Q61711 / Bone sialoprotein 2 / P21815* / integrin binding sialoprotein*  / reaction / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction






 

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