ENSMUSG00000028465


Mus musculus

Features
Gene ID: ENSMUSG00000028465
  
Biological name :Tln1
  
Synonyms : P26039 / talin 1 / Tln1
  
Possible biological names infered from orthology : Q9Y490
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 43531519
Gene end: 43562691
  
Corresponding Affymetrix probe sets: 10512514 (MoGene1.0st)   1436042_at (Mouse Genome 430 2.0 Array)   1448402_at (Mouse Genome 430 2.0 Array)   1457782_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030187
Ensembl peptide - ENSMUSP00000115681
Ensembl peptide - ENSMUSP00000119441
Ensembl peptide - ENSMUSP00000119956
NCBI entrez gene - 21894     See in Manteia.
MGI - MGI:1099832
RefSeq - XM_006537770
RefSeq - NM_011602
RefSeq - XM_006537768
RefSeq - XM_006537769
RefSeq Peptide - NP_035732
swissprot - P26039
swissprot - F6SX70
swissprot - F6S1V7
swissprot - A2AIM2
Ensembl - ENSMUSG00000028465
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tln1ENSDARG00000100729Danio rerio
 TLN1ENSGALG00000002548Gallus gallus
 TLN1ENSG00000137076Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tln2 / talin 2 / Q9Y4G6*ENSMUSG0000005269876
Hip1 / Q8VD75 / Huntingtin-interacting protein 1 / O00291*ENSMUSG000000399599
Hip1r / Q9JKY5 / Huntingtin-interacting protein 1-related protein / O75146* / huntingtin interacting protein 1 related*ENSMUSG000000009159


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032425  Talin, N-terminal F0 domain
 IPR035963  FERM superfamily, second domain
 IPR035964  I/LWEQ domain superfamily
 IPR036476  Talin, central domain superfamily
 IPR036723  Alpha-catenin/vinculin-like superfamily
 IPR037438  Talin-1/2, rod-segment


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007044 cell-substrate junction assembly IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0033622 integrin activation IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0001786 phosphatidylserine binding IMP
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IMP
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IMP
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002594 low mean erythrocyte count "less than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003292 melena "dark colored, foul-smelling feces due to the presence of blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0003405 abnormal platelet shape 
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003423 reduced thrombolysis "reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:17427]
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Allelic Composition: Mecp2tm1Jae/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003939 abnormal myotome morphology "structural anomaly in the mesoderm that is derived from the somite that is fated to beome the musculature" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mecp2tm1Jae/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Orai1Gt(XL922)Byg/Orai1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011207 absent ectoplacental cavity "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011208 small proamniotic cavity "reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Tln1tm3Crit/Tln1tm3Crit
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0011209 absent extraembryonic coelom "absence of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN10:1405118660]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0012104 small amniotic cavity "reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds" [MGI:anna]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000034066 Farp2 / Q91VS8 / FERM, ARHGEF and pleckstrin domain-containing protein 2 / O94887* / FERM, ARH/RhoGEF and pleckstrin domain protein 2*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000034902 O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction / complex
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / reaction / complex
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / reaction / complex
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / reaction / complex
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex






 

1 s.

 
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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr