ENSMUSG00000000915


Mus musculus

Features
Gene ID: ENSMUSG00000000915
  
Biological name :Hip1r
  
Synonyms : Hip1r / Huntingtin-interacting protein 1-related protein / Q9JKY5
  
Possible biological names infered from orthology : huntingtin interacting protein 1 related / O75146
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 123973628
Gene end: 124005558
  
Corresponding Affymetrix probe sets: 10525677 (MoGene1.0st)   1425551_at (Mouse Genome 430 2.0 Array)   1425552_at (Mouse Genome 430 2.0 Array)   1425553_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143309
Ensembl peptide - ENSMUSP00000000939
Ensembl peptide - ENSMUSP00000127361
Ensembl peptide - ENSMUSP00000130766
NCBI entrez gene - 29816     See in Manteia.
MGI - MGI:1352504
RefSeq - XM_006530370
RefSeq - NM_145070
RefSeq - XM_006530369
RefSeq Peptide - NP_659507
swissprot - A0A0G2JFU3
swissprot - Q9JKY5
swissprot - F7DCR9
swissprot - E9Q3C5
Ensembl - ENSMUSG00000000915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hip1raENSDARG00000060627Danio rerio
 hip1rbENSDARG00000102458Danio rerio
 HIP1RENSGALG00000031511Gallus gallus
 HIP1RENSG00000130787Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hip1 / Q8VD75 / Huntingtin-interacting protein 1 / O00291*ENSMUSG0000003995949
Tln2 / talin 2 / Q9Y4G6*ENSMUSG0000005269821
Tln1 / P26039 / talin 1 / Q9Y490*ENSMUSG0000002846521


Protein motifs (from Interpro)
Interpro ID Name
 IPR002558  I/LWEQ domain
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR030224  Sla2 family
 IPR030555  Huntingtin-interacting protein 1-related protein
 IPR032422  Huntingtin-interacting protein 1, clathrin-binding domain
 IPR035964  I/LWEQ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IGI
 biological_processGO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0048268 clathrin coat assembly IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0060453 regulation of gastric acid secretion IMP
 biological_processGO:0061024 membrane organization IMP
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
 biological_processGO:1905445 positive regulation of clathrin coat assembly IDA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis NAS
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis IC
 biological_processGO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097060 synaptic membrane ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0032051 clathrin light chain binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051015 actin filament binding IDA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Dll3oma/Dll3oma
Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr,Hip1rtm1Tsr/Hip1rtm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dll3oma/Dll3oma
Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr,Hip1rtm1Tsr/Hip1rtm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000915 Hip1r / Q9JKY5 / Huntingtin-interacting protein 1-related protein / O75146* / huntingtin interacting protein 1 related*  / complex






 

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