ENSMUSG00000039959


Mus musculus

Features
Gene ID: ENSMUSG00000039959
  
Biological name :Hip1
  
Synonyms : Hip1 / Huntingtin-interacting protein 1 / Q8VD75
  
Possible biological names infered from orthology : O00291
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 135406531
Gene end: 135545120
  
Corresponding Affymetrix probe sets: 10534456 (MoGene1.0st)   1424755_at (Mouse Genome 430 2.0 Array)   1424756_at (Mouse Genome 430 2.0 Array)   1432017_at (Mouse Genome 430 2.0 Array)   1432230_at (Mouse Genome 430 2.0 Array)   1434557_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059033
Ensembl peptide - ENSMUSP00000148842
Ensembl peptide - ENSMUSP00000144429
Ensembl peptide - ENSMUSP00000144392
Ensembl peptide - ENSMUSP00000144086
NCBI entrez gene - 215114     See in Manteia.
MGI - MGI:1099804
RefSeq - XM_011240879
RefSeq - NM_146001
RefSeq - XM_006504415
RefSeq - XM_011240878
RefSeq Peptide - NP_666113
swissprot - A0A1D5RMM7
swissprot - Q8VD75
swissprot - A0A0J9YUX9
swissprot - A0A0J9YUA3
swissprot - A0A0J9YV08
Ensembl - ENSMUSG00000039959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hip1ENSDARG00000062972Danio rerio
 HIP1ENSGALG00000040908Gallus gallus
 HIP1ENSG00000127946Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hip1r / Q9JKY5 / Huntingtin-interacting protein 1-related protein / O75146* / huntingtin interacting protein 1 related*ENSMUSG0000000091551
Tln2 / talin 2 / Q9Y4G6*ENSMUSG0000005269822
Tln1 / P26039 / talin 1 / Q9Y490*ENSMUSG0000002846522


Protein motifs (from Interpro)
Interpro ID Name
 IPR002558  I/LWEQ domain
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR030224  Sla2 family
 IPR030554  Huntingtin-interacting protein 1
 IPR032422  Huntingtin-interacting protein 1, clathrin-binding domain
 IPR035964  I/LWEQ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IEA
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0098793 presynapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0098888 extrinsic component of presynaptic membrane IEA
 cellular_componentGO:0098890 extrinsic component of postsynaptic membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0032051 clathrin light chain binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0035612 AP-2 adaptor complex binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Dll3oma/Dll3oma
Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hip1tm1Tsr/Hip1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Foxl2tm1Gpil/Foxl2tm1Gpil
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * NIHS-BC)

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hip1tm4Tsr/Hip1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr,Hip1rtm1Tsr/Hip1rtm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hip1tm2.1Tsr/Hip1tm2.1Tsr
Genetic Background: involves: 129X1/SvJ

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Celsr1Scy/Celsr1Scy
Genetic Background: involves: BALB/cAnN * C3H/He * C3H/HeH

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mnttm1Awb/Mnttm1.1Awb,Tg(MMTV-cre)4Mam/?
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr,Hip1rtm1Tsr/Hip1rtm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hip1tm4Tsr/Hip1+,Runx1tm3Dow/Runx1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2rgtm1Wjl/Il2rgtm1Wjl,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2rgtm1Wjl Tg(CD2-Ccdc86)1Hfuj

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
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Allelic Composition: Hip1tm3Tsr/Hip1tm3Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
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Allelic Composition: Hip1tm1Tsr/Hip1tm1Tsr
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039959 Hip1 / Q8VD75 / Huntingtin-interacting protein 1 / O00291*  / complex






 

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