ENSMUSG00000052698


Mus musculus

Features
Gene ID: ENSMUSG00000052698
  
Biological name :Tln2
  
Synonyms : talin 2 / Tln2
  
Possible biological names infered from orthology : Q9Y4G6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: C
Gene start: 67217087
Gene end: 67559703
  
Corresponding Affymetrix probe sets: 10594679 (MoGene1.0st)   1429111_at (Mouse Genome 430 2.0 Array)   1429112_at (Mouse Genome 430 2.0 Array)   1435700_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039633
Ensembl peptide - ENSMUSP00000151111
Ensembl peptide - ENSMUSP00000149474
Ensembl peptide - ENSMUSP00000149284
Ensembl peptide - ENSMUSP00000149137
Ensembl peptide - ENSMUSP00000148901
Ensembl peptide - ENSMUSP00000035272
NCBI entrez gene - 70549     See in Manteia.
MGI - MGI:1917799
RefSeq - XM_006511438
RefSeq - XM_006511441
RefSeq - XM_011242811
RefSeq - XM_011242812
RefSeq - XM_011242813
RefSeq - NM_001081242
RefSeq - XM_006511433
RefSeq - XM_006511434
RefSeq Peptide - NP_001074711
swissprot - Q8CDM9
swissprot - A0A1L1SVA8
swissprot - A0A1L1SRI1
swissprot - A0A1L1SQP9
swissprot - A0A1L1SQ51
swissprot - E9PUM4
Ensembl - ENSMUSG00000052698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01046980.1ENSDARG00000112342Danio rerio
 tln2aENSDARG00000017901Danio rerio
 tln2bENSDARG00000110973Danio rerio
 ENSGALG00000046618Gallus gallus
 ENSGALG00000003628Gallus gallus
 ENSGALG00000029816Gallus gallus
 ENSGALG00000046155Gallus gallus
 ENSGALG00000038078Gallus gallus
 TLN2ENSG00000171914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tln1 / P26039 / talin 1 / Q9Y490*ENSMUSG0000002846576
Hip1 / Q8VD75 / Huntingtin-interacting protein 1 / O00291*ENSMUSG000000399599
Hip1r / Q9JKY5 / Huntingtin-interacting protein 1-related protein / O75146* / huntingtin interacting protein 1 related*ENSMUSG000000009159


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032425  Talin, N-terminal F0 domain
 IPR035963  FERM superfamily, second domain
 IPR035964  I/LWEQ domain superfamily
 IPR036476  Talin, central domain superfamily
 IPR036723  Alpha-catenin/vinculin-like superfamily
 IPR037438  Talin-1/2, rod-segment


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
Show

Allelic Composition: Bbc3tm1Gpz/Bbc3tm1Gpz,Trp53tm1Brd/Trp53tm8Xu
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tln2tm1Crit/Tln2tm1Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Tln2Gt(S1-6D1)Sor/Tln2Gt(S1-6D1)Sor
Genetic Background: involves: C57BL/6

Allelic Composition: Tln2tm1Crit/Tln2tm1Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003939 abnormal myotome morphology "structural anomaly in the mesoderm that is derived from the somite that is fated to beome the musculature" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Tln2tm2Crit/Tln2tm2Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh,Tg(RHO-VEGFA)V-6Camp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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