ENSG00000171914


Homo sapiens

Features
Gene ID: ENSG00000171914
  
Biological name :TLN2
  
Synonyms : Q9Y4G6 / talin 2 / TLN2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q22.2
Gene start: 62390526
Gene end: 62844631
  
Corresponding Affymetrix probe sets: 212701_at (Human Genome U133 Plus 2.0 Array)   212703_at (Human Genome U133 Plus 2.0 Array)   232625_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000490662
Ensembl peptide - ENSP00000453508
Ensembl peptide - ENSP00000453730
Ensembl peptide - ENSP00000453812
NCBI entrez gene - 83660     See in Manteia.
OMIM - 607349
RefSeq - XM_017022669
RefSeq - XM_006720717
RefSeq - XM_017022665
RefSeq - XM_017022666
RefSeq - XM_017022667
RefSeq - XM_017022668
RefSeq - NM_015059
RefSeq - XM_005254708
RefSeq - XM_005254710
RefSeq - XM_005254711
RefSeq - XM_005254712
RefSeq - XM_005254713
RefSeq - XM_005254714
RefSeq - XM_005254715
RefSeq Peptide - NP_055874
swissprot - H0YMT1
swissprot - H0YN01
swissprot - A0A1B0GVU7
swissprot - Q9Y4G6
Ensembl - ENSG00000171914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01046980.1ENSDARG00000112342Danio rerio
 tln2aENSDARG00000017901Danio rerio
 tln2bENSDARG00000110973Danio rerio
 ENSGALG00000038078Gallus gallus
 ENSGALG00000029816Gallus gallus
 ENSGALG00000046618Gallus gallus
 ENSGALG00000003628Gallus gallus
 ENSGALG00000046155Gallus gallus
 Tln2ENSMUSG00000052698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLN1 / Q9Y490 / talin 1ENSG0000013707676
HIP1 / O00291 / huntingtin interacting protein 1ENSG000001279469
HIP1R / O75146 / huntingtin interacting protein 1 relatedENSG000001307879


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032425  Talin, N-terminal F0 domain
 IPR035963  FERM superfamily, second domain
 IPR035964  I/LWEQ domain superfamily
 IPR036476  Talin, central domain superfamily
 IPR036723  Alpha-catenin/vinculin-like superfamily
 IPR037438  Talin-1/2, rod-segment


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007043 cell-cell junction assembly TAS
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0015629 actin cytoskeleton NAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse NAS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005198 structural molecule activity NAS
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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