ENSG00000137076


Homo sapiens

Features
Gene ID: ENSG00000137076
  
Biological name :TLN1
  
Synonyms : Q9Y490 / talin 1 / TLN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p13.3
Gene start: 35696948
Gene end: 35732395
  
Corresponding Affymetrix probe sets: 203254_s_at (Human Genome U133 Plus 2.0 Array)   232763_at (Human Genome U133 Plus 2.0 Array)   236132_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000316029
NCBI entrez gene - 7094     See in Manteia.
OMIM - 186745
RefSeq - NM_006289
RefSeq Peptide - NP_006280
swissprot - Q9Y490
Ensembl - ENSG00000137076
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tln1ENSDARG00000100729Danio rerio
 TLN1ENSGALG00000002548Gallus gallus
 Tln1ENSMUSG00000028465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLN2 / Q9Y4G6 / talin 2ENSG0000017191476
HIP1 / O00291 / huntingtin interacting protein 1ENSG000001279469
HIP1R / O75146 / huntingtin interacting protein 1 relatedENSG000001307879


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032425  Talin, N-terminal F0 domain
 IPR035963  FERM superfamily, second domain
 IPR035964  I/LWEQ domain superfamily
 IPR036476  Talin, central domain superfamily
 IPR036723  Alpha-catenin/vinculin-like superfamily
 IPR037438  Talin-1/2, rod-segment


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane NAS
 biological_processGO:0007043 cell-cell junction assembly TAS
 biological_processGO:0007044 cell-substrate junction assembly IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0070527 platelet aggregation HMP
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017166 vinculin binding IPI
 molecular_functionGO:0030274 LIM domain binding IPI
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
XBP1(S) activates chaperone genes
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / complex / reaction
 ENSG00000035403 VCL / P18206 / vinculin  / complex
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / complex / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction / complex
 ENSG00000006607 FARP2 / O94887 / FERM, ARH/RhoGEF and pleckstrin domain protein 2  / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / reaction / complex
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000186111 O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma  / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction / complex
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / complex / reaction
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction / complex






 

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