ENSG00000130787


Homo sapiens

Features
Gene ID: ENSG00000130787
  
Biological name :HIP1R
  
Synonyms : HIP1R / huntingtin interacting protein 1 related / O75146
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 122834453
Gene end: 122862960
  
Corresponding Affymetrix probe sets: 209558_s_at (Human Genome U133 Plus 2.0 Array)   209559_at (Human Genome U133 Plus 2.0 Array)   38340_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000253083
Ensembl peptide - ENSP00000446236
NCBI entrez gene - 9026     See in Manteia.
OMIM - 605613
RefSeq - XM_011538963
RefSeq - NM_003959
RefSeq Peptide - NP_003950
swissprot - O75146
swissprot - H0YH66
Ensembl - ENSG00000130787
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hip1raENSDARG00000060627Danio rerio
 hip1rbENSDARG00000102458Danio rerio
 HIP1RENSGALG00000031511Gallus gallus
 Hip1rENSMUSG00000000915Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIP1 / O00291 / huntingtin interacting protein 1ENSG0000012794649
TLN2 / Q9Y4G6 / talin 2ENSG0000017191421
TLN1 / Q9Y490 / talin 1ENSG0000013707621


Protein motifs (from Interpro)
Interpro ID Name
 IPR002558  I/LWEQ domain
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR030224  Sla2 family
 IPR030555  Huntingtin-interacting protein 1-related protein
 IPR032422  Huntingtin-interacting protein 1, clathrin-binding domain
 IPR035964  I/LWEQ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0030100 regulation of endocytosis NAS
 biological_processGO:0030837 negative regulation of actin filament polymerization IMP
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IMP
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0055123 digestive system development IEA
 biological_processGO:0060453 regulation of gastric acid secretion IEA
 biological_processGO:0061024 membrane organization IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IGI
 biological_processGO:1905445 positive regulation of clathrin coat assembly IEA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis NAS
 biological_processGO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0032839 dendrite cytoplasm ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097060 synaptic membrane ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0032051 clathrin light chain binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0035615 clathrin adaptor activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130787 HIP1R / O75146 / huntingtin interacting protein 1 related  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr