ENSGALG00000002548


Gallus gallus

Features
Gene ID: ENSGALG00000002548
  
Biological name :TLN1
  
Synonyms : talin-1 / TLN1
  
Possible biological names infered from orthology : P26039 / Q9Y490
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 9172914
Gene end: 9207118
  
Corresponding Affymetrix probe sets: Gga.4319.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004013
Ensembl peptide - ENSGALP00000056315
NCBI entrez gene - 395194     See in Manteia.
RefSeq - XM_015277233
RefSeq - XM_015277230
RefSeq - XM_015277231
RefSeq - XM_015277232
RefSeq - NM_204523
RefSeq - XM_015277228
RefSeq Peptide - NP_989854
swissprot - E1C2S1
swissprot - A0A1D5PTR5
Ensembl - ENSGALG00000002548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tln1ENSDARG00000100729Danio rerio
 TLN1ENSG00000137076Homo sapiens
 Tln1ENSMUSG00000028465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLN2* / Q9Y4G6* / talin 2*ENSGALG0000000362818
TLN2* / Q9Y4G6* / talin 2*ENSGALG0000004661811
TLN2* / Q9Y4G6* / talin 2*ENSGALG000000380789
TLN2* / Q9Y4G6* / talin 2*ENSGALG000000298169
HIP1R / huntingtin-interacting protein 1-related protein / O75146* / Q9JKY5* / huntingtin interacting protein 1 related*ENSGALG000000315119
HIP1 / huntingtin interacting protein 1 / O00291* / Q8VD75*ENSGALG000000409088
TLN2* / Q9Y4G6* / talin 2*ENSGALG000000461554


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR006077  Vinculin/alpha-catenin
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032425  Talin, N-terminal F0 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007044 cell-substrate junction assembly IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IEA
 biological_processGO:0033622 integrin activation IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0017166 vinculin binding IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction / complex
 ENSGALG00000000784 PIP5K1C / Gallus gallus phosphatidylinositol-4-phosphate 5-kinase, type I, gamma (PIP5K1C), mRNA. / O60331* / O70161* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / reaction / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000031270 CSK / tyrosine-protein kinase CSK / P41240* / P41241* / C-terminal Src kinase*  / complex / reaction
 ENSGALG00000005079 VCL / P12003 / Vinculin / P18206* / Q64727*  / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000005788 FARP2 / FERM, ARH/RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction






 

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