ENSDARG00000100729


Danio rerio

Features
Gene ID: ENSDARG00000100729
  
Biological name :tln1
  
Synonyms : talin 1 / tln1
  
Possible biological names infered from orthology : P26039 / Q9Y490
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 6121558
Gene end: 6313905
  
Corresponding Affymetrix probe sets: Dr.4098.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000132453
Ensembl peptide - ENSDARP00000139853
NCBI entrez gene - 494453     See in Manteia.
RefSeq - NM_001009560
RefSeq - XM_005155500
RefSeq - XM_021479168
RefSeq Peptide - NP_001009560
swissprot - Q5U7N6
swissprot - A0A0R4IXS5
swissprot - A0A0R4IDZ8
ZFIN ID - ZDB-GENE-031002-48
Ensembl - ENSDARG00000100729
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLN1ENSGALG00000002548Gallus gallus
 TLN1ENSG00000137076Homo sapiens
 Tln1ENSMUSG00000028465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tln2a / talin 2a / TLN2* / Q9Y4G6* / talin 2*ENSDARG0000001790175
tln2b / talin 2b / TLN2* / Q9Y4G6* / talin 2*ENSDARG0000011097344
CABZ01046980.1 / TLN2* / Q9Y4G6* / talin 2*ENSDARG0000011234210
hip1 / huntingtin interacting protein 1 / O00291* / Q8VD75*ENSDARG000000629729
hip1rb / huntingtin interacting protein 1 related b / HIP1R* / O75146* / Q9JKY5* / huntingtin interacting protein 1 related* / Huntingtin-interacting protein 1-related protein *ENSDARG000001024588
hip1ra / huntingtin interacting protein 1 related a / HIP1R* / O75146* / huntingtin interacting protein 1 related*ENSDARG000000606273


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR002558  I/LWEQ domain
 IPR006077  Vinculin/alpha-catenin
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR015009  Vinculin-binding site-containing domain
 IPR015224  Talin, central
 IPR018979  FERM, N-terminal
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR032425  Talin, N-terminal F0 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007016 cytoskeletal anchoring at plasma membrane IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0061386 closure of optic fissure IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Smooth Muscle Contraction
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
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 ZFA:0000114 heart heart quality , abnormal
heart hemorrhagic , abnormal
heart decreased volume , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein decreased diameter , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased amount , abnormal
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 ZFA:0001320 endocardium endocardium separated from myocardium , abnormal
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 ZFA:0001639 vascular endothelium vascular endothelium filamentous actin decreased amount , abnormal
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 ZFA:0005035 subintestinal vein subintestinal vein morphology , abnormal
subintestinal vein blood vessel morphogenesis disrupted , abnormal
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 ZFA:0005046 hyaloid vessel hyaloid vessel hypotrophic , abnormal
hyaloid vessel decreased distribution , abnormal
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 ZFA:0005061 ventricular myocardium ventricular myocardium Z disc amount , ameliorated
ventricular myocardium Z disc decreased amount , abnormal
ventricular myocardium striated muscle thin filament decreased amount , abnormal
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 ZFA:0005280 cardiac muscle cardiac muscle Z disc spatial pattern , abnormal
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 ZFA:0005491 optic furrow optic furrow basement membrane present , abnormal
optic furrow basement membrane increased distribution , abnormal
optic furrow basement membrane disassembly disrupted , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell Z disc disorganized , abnormal
cardiac muscle cell decreased size , abnormal
cardiac muscle cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000076001 pip5k1ca / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction / complex
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000075437 shc1 / SHC (Src homology 2 domain containing) transforming protein 1 / P98083* / P29353* / SHC adaptor protein 1* / SHC-transforming protein 1 *  / reaction / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / reaction / complex
 ENSDARG00000016429 farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / reaction / complex
 ENSDARG00000100313 pip5k1cb / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*  / complex






 

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