ENSDARG00000008969


Danio rerio

Features
Gene ID: ENSDARG00000008969
  
Biological name :fgb
  
Synonyms : fgb / fibrinogen beta chain
  
Possible biological names infered from orthology : Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675 / Q8K0E8
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 10051763
Gene end: 10059496
  
Corresponding Affymetrix probe sets: Dr.5462.1.S1_at (Zebrafish Array)   NM_212774_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000016228
NCBI entrez gene - 337315     See in Manteia.
RefSeq - NM_212774
RefSeq Peptide - NP_997939
swissprot - Q6NYE1
ZFIN ID - ZDB-GENE-030131-9261
Ensembl - ENSDARG00000008969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGBENSGALG00000009262Gallus gallus
 FGBENSG00000171564Homo sapiens
 FgbENSMUSG00000033831Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*ENSDARG0000003728127
fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSDARG0000002074126
fgl1 / fibrinogen-like 1 / Q08830*ENSDARG0000010538023
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSDARG0000004436522
tnc / tenascin C / P24821* / Q80YX1*ENSDARG0000002194822
si:ch211-287a12.9ENSDARG0000005700422
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*ENSDARG0000002077122
zmp:0000000846 / TNC* / P24821* / tenascin C*ENSDARG0000007836221
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*ENSDARG0000000176021
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSDARG0000003585921
tnn / tenascin N / Q80Z71* / Q9UQP3*ENSDARG0000002482920
angptl5 / angiopoietin-like 5 / Q86XS5*ENSDARG0000005663019
fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000001981516
zgc:194887ENSDARG0000009858615
fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000000652615


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IMP
 cellular_componentGO:0005577 fibrinogen complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / reaction / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000016939 itgb2 / integrin, beta 2 / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *  / reaction / complex
 ENSDARG00000002956 si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...  / reaction / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction / complex
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction / complex






 

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