ENSDARG00000020741


Danio rerio

Features
Gene ID: ENSDARG00000020741
  
Biological name :fga
  
Synonyms : fga / fibrinogen alpha chain
  
Possible biological names infered from orthology : E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 10063501
Gene end: 10071539
  
Corresponding Affymetrix probe sets: Dr.845.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000029074
Ensembl peptide - ENSDARP00000123307
NCBI entrez gene - 378986     See in Manteia.
RefSeq - NM_001194989
RefSeq Peptide - NP_001181918
swissprot - E9QCD1
swissprot - B8A5L6
ZFIN ID - ZDB-GENE-031010-21
Ensembl - ENSDARG00000020741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGAENSGALG00000009266Gallus gallus
 FGAENSG00000171560Homo sapiens
 FgaENSMUSG00000028001Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*ENSDARG0000003728119
tnc / tenascin C / P24821* / Q80YX1*ENSDARG0000002194819
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*ENSDARG0000002077118
zmp:0000000846 / TNC* / P24821* / tenascin C*ENSDARG0000007836218
fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*ENSDARG0000000896918
fgl1 / fibrinogen-like 1 / Q08830*ENSDARG0000010538017
tnn / tenascin N / Q80Z71* / Q9UQP3*ENSDARG0000002482917
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*ENSDARG0000000176017
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSDARG0000004436516
si:ch211-287a12.9ENSDARG0000005700415
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSDARG0000003585915
angptl5 / angiopoietin-like 5 / Q86XS5*ENSDARG0000005663013
fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000001981512
fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000000652612
zgc:194887ENSDARG0000009858611


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IGI
 cellular_componentGO:0005577 fibrinogen complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008969 fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction
 ENSDARG00000016939 itgb2 / integrin, beta 2 / Itgb2l* / P05107* / Q3UV74* / integrin subunit beta 2* / Integrin beta-2-like protein *  / complex / reaction
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000002956 si:dkey-32n7.4 / ITGAD* / ITGAM* / ITGAX* / Q13349* / P11215* / P20702* / Q9QXH4* / Q3V0T4* / integrin alpha M* / Integrin alpha-X * / Integrin alpha-D * / integrin subunit alpha X* / integ...  / reaction / complex
 ENSDARG00000020741 fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*  / complex / reaction
 ENSDARG00000037281 fgg / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / reaction / complex
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction / complex






 

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