ENSDARG00000006526


Danio rerio

Features
Gene ID: ENSDARG00000006526
  
Biological name :fn1b
  
Synonyms : fibronectin 1b / fn1b
  
Possible biological names infered from orthology : fibronectin 1 / Fibronectin Anastellin / FN1 / P02751 / P11276
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 5504128
Gene end: 5543065
  
Corresponding Affymetrix probe sets: Dr.24233.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000094530
Ensembl peptide - ENSDARP00000141528
Ensembl peptide - ENSDARP00000131015
NCBI entrez gene - 334613     See in Manteia.
RefSeq - XM_009305554
swissprot - A2CEW3
swissprot - A0A0R4IXY1
swissprot - A0A0R4IDI3
ZFIN ID - ZDB-GENE-030131-6545
Ensembl - ENSDARG00000006526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FN1ENSGALG00000003578Gallus gallus
 FN1ENSG00000115414Homo sapiens
 Fn1ENSMUSG00000026193Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*ENSDARG0000001981563
zmp:0000000846 / TNC* / P24821* / tenascin C*ENSDARG0000007836213
tnc / tenascin C / P24821* / Q80YX1*ENSDARG0000002194813
tnr / tenascin R (restrictin, janusin) / Q8BYI9* / Q92752* / tenascin R*ENSDARG0000002077112
tnn / tenascin N / Q80Z71* / Q9UQP3*ENSDARG000000248298
tnxba / tenascin XBa / TNXB* / P22105* / tenascin XB*ENSDARG000000017606
angptl4 / angiopoietin-like 4 / Q9BY76* / Q9Z1P8* / Angiopoietin-related protein 4 *ENSDARG000000358593
angptl3 / angiopoietin-like 3 / Q9R182* / Q9Y5C1* / Angiopoietin-related protein 3 ANGPTL3(17-224)*ENSDARG000000443653
fgb / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*ENSDARG000000089693
fgg / fibrinogen gamma chain / P02679* / Q8VCM7*ENSDARG000000372813
fga / fibrinogen alpha chain / E9PV24* / P02671* / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain*ENSDARG000000207413
si:ch211-287a12.9ENSDARG000000570042
zgc:194887ENSDARG000000985862
fgl1 / fibrinogen-like 1 / Q08830*ENSDARG000001053802
angptl5 / angiopoietin-like 5 / Q86XS5*ENSDARG000000566302


Protein motifs (from Interpro)
Interpro ID Name
 IPR000083  Fibronectin, type I
 IPR000562  Fibronectin type II domain
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0003128 heart field specification IGI
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Degradation of the extracellular matrix
Extracellular matrix organization
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite shape , abnormal
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 ZFA:0001056 myotome myotome actin filament increased length , abnormal
myotome actin filament disorganized , abnormal
myotome myosin filament disorganized , abnormal
myotome increased size , abnormal
myotome variant shape , abnormal
myotome muscle tendon junction morphology , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal cell spatial pattern , abnormal
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 ZFA:0001318 cardiac jelly cardiac jelly cell decreased amount , abnormal
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 ZFA:0001462 somite border somite border shape , abnormal
somite border aplastic , abnormal
Show

 ZFA:0005064 atrioventricular valve atrioventricular valve morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006353 itga5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / P08648* / P11688* / integrin subunit alpha 5* / Integrin alpha-5 Integrin alpha-5 heavy chain Integrin alpha-5 light chain*  / complex / reaction
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000021948 tnc / tenascin C / P24821* / Q80YX1*  / reaction / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000071863 itgb1a / integrin, beta 1a / ITGB1* / P05556* / P09055* / Integrin beta-1 * / integrin subunit beta 1*  / complex / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000015156 fbln2 / fibulin 2 / P37889* / P98095*  / reaction / complex
 ENSDARG00000078362 zmp:0000000846 / TNC* / P24821* / tenascin C*  / complex / reaction
 ENSDARG00000019815 fn1a / fibronectin 1a / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / - / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / complex / reaction
 ENSDARG00000006526 fn1b / fibronectin 1b / FN1* / P02751* / P11276* / fibronectin 1* / Fibronectin Anastellin*  / - / reaction / complex
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / reaction / complex






 

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