ENSDARG00000077231


Danio rerio

Features
Gene ID: ENSDARG00000077231
  
Biological name :vwf
  
Synonyms : von Willebrand factor / vwf
  
Possible biological names infered from orthology : P04275
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 7150144
Gene end: 7228004
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000116546
Ensembl peptide - ENSDARP00000101847
Ensembl peptide - ENSDARP00000114975
NCBI entrez gene - 570643     See in Manteia.
RefSeq - XM_002665310
RefSeq - NM_001281989
RefSeq Peptide - NP_001268918
swissprot - F1R1J2
swissprot - E7F9Z1
swissprot - F1QHS6
swissprot - F5XVB3
ZFIN ID - ZDB-GENE-070103-1
Ensembl - ENSDARG00000077231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VWFENSGALG00000017272Gallus gallus
 VWFENSG00000110799Homo sapiens
 VwfENSMUSG00000001930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
muc5.2 / mucin 5.2 / MUC5B* / MUC5AC* / P98088* / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming* / mucin 5AC, oligomeric mucus/gel-forming*ENSDARG0000005855623
muc5.1 / mucin 5.1, oligomeric mucus/gel-forming / MUC5B* / MUC5AC* / P98088* / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming* / mucin 5AC, oligomeric mucus/gel-forming*ENSDARG0000007033122
muc5.3 / mucin 5.3 / MUC5B* / MUC5AC* / P98088* / Q9HC84* / mucin 5B, oligomeric mucus/gel-forming* / mucin 5AC, oligomeric mucus/gel-forming*ENSDARG0000009947022
otog / otogelin / Q6ZRI0*ENSDARG0000006846021
otogl / otogelin-like / F7A4A7* / Q3ZCN5* / Otogelin-like protein *ENSDARG0000008875020
scospondin / subcommissural organ spondin / SSPO* / Q8CG65* / SCO-spondin*ENSDARG0000006785920
si:ch211-39f2.3ENSDARG0000009753915
zanl / zonadhesin, like / ZAN* / zonadhesin* / zonadhesin (gene/pseudogene)*ENSDARG0000005678115
CABZ01080550.1ENSDARG0000010062114
si:dkey-65b12.6 / FCGBP* / 9530053A07Rik* / RIKEN cDNA 9530053A07 gene* / Fc fragment of IgG binding protein*ENSDARG0000007683014
tecta / tectorin alpha / O08523* / O75443*ENSDARG0000005955813
si:dkey-239b22.1ENSDARG0000003158811


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR002035  von Willebrand factor, type A
 IPR002919  Trypsin Inhibitor-like, cysteine rich domain
 IPR006207  Cystine knot, C-terminal
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR032361  von Willebrand factor, VWA N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007599 hemostasis IMP
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation
Platelet Adhesion to exposed collagen


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk hemorrhagic , abnormal
Show

 ZFA:0001114 head head hemorrhagic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044968 vcla / vinculin a / VCL* / Q64727* / P18206* / vinculin*  / complex
 ENSDARG00000008867 rap1b / Q6TEN1 / RAP1B, member of RAS oncogene family / Q99JI6* / P61224* / RAS related protein 1b*  / complex / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000012553 rap1aa / RAP1A, member of RAS oncogene family a / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSDARG00000007923 ptpn1 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSDARG00000067996 csk / C-terminal Src kinase / P41240* / P41241* / Tyrosine-protein kinase CSK *  / complex / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000055635 crk / v-crk avian sarcoma virus CT10 oncogene homolog / P46108* / Q64010* / Adapter molecule crk * / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSDARG00000077231 vwf / von Willebrand factor / P04275*  / - / complex
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000056525 bcar1 / breast cancer anti-estrogen resistance 1 / Q61140* / P56945* / BCAR1, Cas family scaffolding protein* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSDARG00000087346 rap1ab / RAP1A, member of RAS oncogene family b / RAP1B* / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSDARG00000100729 tln1 / talin 1 / P26039* / Q9Y490*  / complex / reaction






 

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