ENSG00000050820


Homo sapiens

Features
Gene ID: ENSG00000050820
  
Biological name :BCAR1
  
Synonyms : BCAR1 / BCAR1, Cas family scaffolding protein / P56945
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q23.1
Gene start: 75228187
Gene end: 75268053
  
Corresponding Affymetrix probe sets: 223116_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458088
Ensembl peptide - ENSP00000457231
Ensembl peptide - ENSP00000457457
Ensembl peptide - ENSP00000162330
Ensembl peptide - ENSP00000377072
Ensembl peptide - ENSP00000377074
Ensembl peptide - ENSP00000391669
Ensembl peptide - ENSP00000392708
Ensembl peptide - ENSP00000440370
Ensembl peptide - ENSP00000440415
Ensembl peptide - ENSP00000442161
Ensembl peptide - ENSP00000443841
Ensembl peptide - ENSP00000454702
Ensembl peptide - ENSP00000455166
Ensembl peptide - ENSP00000455810
Ensembl peptide - ENSP00000456625
Ensembl peptide - ENSP00000456929
Ensembl peptide - ENSP00000457097
NCBI entrez gene - 9564     See in Manteia.
OMIM - 602941
RefSeq - XM_017023899
RefSeq - NM_001170714
RefSeq - NM_001170715
RefSeq - NM_001170716
RefSeq - NM_001170717
RefSeq - NM_001170718
RefSeq - NM_001170719
RefSeq - NM_001170720
RefSeq - NM_001170721
RefSeq - NM_014567
RefSeq - XM_005256258
RefSeq - XM_005256259
RefSeq - XM_005256260
RefSeq - XM_011523475
RefSeq - XM_017023897
RefSeq - XM_017023898
RefSeq Peptide - NP_001164185
RefSeq Peptide - NP_001164186
RefSeq Peptide - NP_001164187
RefSeq Peptide - NP_001164188
RefSeq Peptide - NP_001164189
RefSeq Peptide - NP_001164190
RefSeq Peptide - NP_001164191
RefSeq Peptide - NP_001164192
RefSeq Peptide - NP_055382
swissprot - H3BVF0
swissprot - H3BTL5
swissprot - F5H855
swissprot - H3BN62
swissprot - H3BQJ7
swissprot - H3BSB2
swissprot - H3BSY4
swissprot - H3BTB0
swissprot - P56945
swissprot - H3BU42
Ensembl - ENSG00000050820
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcar1ENSDARG00000056525Danio rerio
 BCAR1ENSGALG00000042895Gallus gallus
 Bcar1ENSMUSG00000031955Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEDD9 / Q14511 / neural precursor cell expressed, developmentally down-regulated 9ENSG0000011185937
EFS / O43281 / embryonal Fyn-associated substrateENSG0000010084223
CASS4 / Q9NQ75 / Cas scaffolding protein family member 4ENSG0000008758922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR014928  Serine rich protein interaction domain
 IPR021901  CAS family, C-terminal
 IPR028848  Breast cancer anti-estrogen resistance protein 1
 IPR035745  BCAR1, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR037362  CAS family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth TAS
 biological_processGO:0007015 actin filament organization IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway NAS
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IMP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway ISS
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IMP
 biological_processGO:0050851 antigen receptor-mediated signaling pathway IDA
 biological_processGO:0050852 T cell receptor signaling pathway NAS
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051301 cell division NAS
 biological_processGO:0060326 cell chemotaxis IMP
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction / complex
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / reaction / complex
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / complex / reaction
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / complex / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / complex / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / reaction / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / reaction / complex
 ENSG00000107263 Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1  / complex / reaction






 

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