ENSG00000080824


Homo sapiens

Features
Gene ID: ENSG00000080824
  
Biological name :HSP90AA1
  
Synonyms : heat shock protein 90 alpha family class A member 1 / HSP90AA1 / P07900
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.31
Gene start: 102080738
Gene end: 102139699
  
Corresponding Affymetrix probe sets: 210211_s_at (Human Genome U133 Plus 2.0 Array)   211968_s_at (Human Genome U133 Plus 2.0 Array)   211969_at (Human Genome U133 Plus 2.0 Array)   214328_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452241
Ensembl peptide - ENSP00000451400
Ensembl peptide - ENSP00000489370
Ensembl peptide - ENSP00000216281
Ensembl peptide - ENSP00000335153
Ensembl peptide - ENSP00000450712
NCBI entrez gene - 3320     See in Manteia.
OMIM - 140571
RefSeq - XM_011536718
RefSeq - NM_001017963
RefSeq - NM_005348
RefSeq Peptide - NP_001017963
RefSeq Peptide - NP_005339
swissprot - P07900
swissprot - A0A0U1RR69
swissprot - G3V2J8
swissprot - H0YJF5
swissprot - G3V592
swissprot - K9JA46
Ensembl - ENSG00000080824
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q90474ENSDARG00000010478Danio rerio
 HSP90AA1ENSGALG00000033212Gallus gallus
 P07901ENSMUSG00000021270Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1ENSG0000009638473
P14625 / HSP90B1 / heat shock protein 90 beta family member 1ENSG0000016659840
TRAP1 / Q12931 / TNF receptor associated protein 1ENSG0000012660225


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006839 mitochondrial transport TAS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006986 response to unfolded protein NAS
 biological_processGO:0007004 telomere maintenance via telomerase IDA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0009408 response to heat ISS
 biological_processGO:0009409 response to cold ISS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0021955 central nervous system neuron axonogenesis IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0032273 positive regulation of protein polymerization IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042026 protein refolding TAS
 biological_processGO:0043254 regulation of protein complex assembly NAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043335 protein unfolding NAS
 biological_processGO:0045040 protein import into mitochondrial outer membrane IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0046677 response to antibiotic ISS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0050821 protein stabilization TAS
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051131 chaperone-mediated protein complex assembly IDA
 biological_processGO:0051186 cofactor metabolic process TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0061684 chaperone-mediated autophagy TAS
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1902949 positive regulation of tau-protein kinase activity IDA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IGI
 biological_processGO:1905323 telomerase holoenzyme complex assembly IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004713 protein tyrosine kinase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IEA
 molecular_functionGO:0030911 TPR domain binding TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0048156 tau protein binding IPI
 molecular_functionGO:0051020 GTPase binding IPI
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IPI
 molecular_functionGO:0097110 scaffold protein binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IPI
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
vRNP Assembly
Regulation of actin dynamics for phagocytic cup formation
eNOS activation
Regulation of PLK1 Activity at G2/M Transition
Scavenging by Class F Receptors
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Uptake and function of diphtheria toxin
PIWI-interacting RNA (piRNA) biogenesis
Anchoring of the basal body to the plasma membrane
Constitutive Signaling by EGFRvIII
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Downregulation of ERBB2 signaling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex / reaction
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / complex / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000169083 AR / P10275 / androgen receptor  / complex
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000164867 NOS3 / P29474 / nitric oxide synthase 3  / reaction / complex
 ENSG00000077800 FKBP6 / O75344 / FK506 binding protein 6  / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000151623 NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2  / complex
 ENSG00000113580 NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1  / complex
 ENSG00000082175 PGR / P06401 / progesterone receptor  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction
 ENSG00000140009 ESR2 / Q92731 / estrogen receptor 2  / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction
 ENSG00000105974 CAV1 / Q03135 / caveolin 1  / reaction / complex
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / reaction / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction
 ENSG00000105401 CDC37 / Q16543 / cell division cycle 37  / reaction / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / reaction / complex
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex / reaction
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000112851 ERBIN / Q96RT1 / erbb2 interacting protein  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction / complex
 ENSG00000171497 PPID / Q08752 / peptidylprolyl isomerase D  / complex
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / reaction
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / complex / reaction
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000204315 FKBPL / Q9UIM3 / FK506 binding protein like  / reaction / complex
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction / complex
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / reaction / complex
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction
 ENSG00000075218 GTSE1 / Q9NYZ3 / G2 and S-phase expressed 1  / reaction / complex
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction






 

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