ENSG00000120899


Homo sapiens

Features
Gene ID: ENSG00000120899
  
Biological name :PTK2B
  
Synonyms : protein tyrosine kinase 2 beta / PTK2B / Q14289
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.2
Gene start: 27311482
Gene end: 27459391
  
Corresponding Affymetrix probe sets: 203110_at (Human Genome U133 Plus 2.0 Array)   203111_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427931
Ensembl peptide - ENSP00000416174
Ensembl peptide - ENSP00000428271
Ensembl peptide - ENSP00000430404
Ensembl peptide - ENSP00000429694
Ensembl peptide - ENSP00000428837
Ensembl peptide - ENSP00000332816
Ensembl peptide - ENSP00000380638
Ensembl peptide - ENSP00000391995
NCBI entrez gene - 2185     See in Manteia.
OMIM - 601212
RefSeq - XM_017013216
RefSeq - NM_004103
RefSeq - NM_173174
RefSeq - NM_173175
RefSeq - NM_173176
RefSeq - XM_005273447
RefSeq - XM_005273448
RefSeq - XM_011544441
RefSeq - XM_011544442
RefSeq - XM_017013214
RefSeq - XM_017013215
RefSeq Peptide - NP_775266
RefSeq Peptide - NP_775267
RefSeq Peptide - NP_775268
RefSeq Peptide - NP_004094
swissprot - C9JHV9
swissprot - E5RK84
swissprot - Q14289
swissprot - E5RJ77
swissprot - E5RHL2
swissprot - H0YB74
Ensembl - ENSG00000120899
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk2baENSDARG00000022841Danio rerio
 ptk2bbENSDARG00000039577Danio rerio
 PTK2BENSGALG00000016564Gallus gallus
 Ptk2bENSMUSG00000059456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTK2 / Q05397 / protein tyrosine kinase 2ENSG0000016939846
ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4ENSG0000017856820
EGFR / P00533 / epidermal growth factor receptorENSG0000014664820
ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2ENSG0000014173619
ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3ENSG0000006536118
TNK2 / Q07912 / tyrosine kinase non receptor 2ENSG0000006193815
TNK1 / Q13470 / tyrosine kinase non receptor 1ENSG0000017429214
ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70ENSG0000011508513
SYK / P43405 / spleen associated tyrosine kinaseENSG0000016502513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030610  Protein-tyrosine kinase 2-beta
 IPR035963  FERM superfamily, second domain
 IPR036137  Focal adhesion kinase, targeting (FAT) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002315 marginal zone B cell differentiation ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002688 regulation of leukocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006968 cellular defense response ISS
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007172 signal complex assembly TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010656 negative regulation of muscle cell apoptotic process IEA
 biological_processGO:0010752 regulation of cGMP-mediated signaling IEA
 biological_processGO:0010758 regulation of macrophage chemotaxis ISS
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization ISS
 biological_processGO:0030826 obsolete regulation of cGMP biosynthetic process IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032960 regulation of inositol trisphosphate biosynthetic process ISS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway ISS
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation ISS
 biological_processGO:0038110 interleukin-2-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042976 activation of Janus kinase activity IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045428 regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045453 bone resorption ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0048167 regulation of synaptic plasticity TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050848 regulation of calcium-mediated signaling IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IDA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2000114 regulation of establishment of cell polarity ISS
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization ISS
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISS
 biological_processGO:2000538 positive regulation of B cell chemotaxis ISS
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex ISS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body ISS
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097440 apical dendrite ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity ISS
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0004972 NMDA glutamate receptor activity ISS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043423 3-phosphoinositide-dependent protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / complex / reaction
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction / complex
 ENSG00000196776 CD47 / Q08722 / CD47 molecule  / complex / reaction
 ENSG00000198053 SIRPA / P78324 / signal regulatory protein alpha  / reaction / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / complex / reaction






 

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