ENSG00000061938


Homo sapiens

Features
Gene ID: ENSG00000061938
  
Biological name :TNK2
  
Synonyms : Q07912 / TNK2 / tyrosine kinase non receptor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q29
Gene start: 195863364
Gene end: 195911945
  
Corresponding Affymetrix probe sets: 1555557_a_at (Human Genome U133 Plus 2.0 Array)   1565783_at (Human Genome U133 Plus 2.0 Array)   203838_s_at (Human Genome U133 Plus 2.0 Array)   203839_s_at (Human Genome U133 Plus 2.0 Array)   216439_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395588
Ensembl peptide - ENSP00000395154
Ensembl peptide - ENSP00000398614
Ensembl peptide - ENSP00000415126
Ensembl peptide - ENSP00000409462
Ensembl peptide - ENSP00000329425
Ensembl peptide - ENSP00000371341
Ensembl peptide - ENSP00000390088
Ensembl peptide - ENSP00000390435
Ensembl peptide - ENSP00000392253
Ensembl peptide - ENSP00000392546
Ensembl peptide - ENSP00000393707
NCBI entrez gene - 10188     See in Manteia.
OMIM - 606994
RefSeq - XM_017005510
RefSeq - NM_001010938
RefSeq - NM_001308046
RefSeq - NM_005781
RefSeq - XM_005269268
RefSeq - XM_005269270
RefSeq - XM_005269274
RefSeq - XM_005269275
RefSeq - XM_011512317
RefSeq - XM_011512318
RefSeq - XM_011512320
RefSeq - XM_011512321
RefSeq - XM_017005508
RefSeq - XM_017005509
RefSeq Peptide - NP_005772
RefSeq Peptide - NP_001010938
RefSeq Peptide - NP_001294975
swissprot - H0Y5H7
swissprot - H7BZM8
swissprot - H7BZZ3
swissprot - C9JIR5
swissprot - H7C412
swissprot - Q07912
swissprot - C9J1X3
swissprot - H7C343
swissprot - C9JDG3
swissprot - F8WER3
Ensembl - ENSG00000061938
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnk2aENSDARG00000090646Danio rerio
 tnk2bENSDARG00000104409Danio rerio
 TNK2ENSGALG00000027983Gallus gallus
 Tnk2ENSMUSG00000022791Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNK1 / Q13470 / tyrosine kinase non receptor 1ENSG0000017429224
ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2ENSG0000014173617
ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4ENSG0000017856816
ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3ENSG0000006536116
EGFR / P00533 / epidermal growth factor receptorENSG0000014664816
PTK2 / Q05397 / protein tyrosine kinase 2ENSG0000016939816
PTK2B / Q14289 / protein tyrosine kinase 2 betaENSG0000012089914
SYK / P43405 / spleen associated tyrosine kinaseENSG0000016502512
ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70ENSG0000011508511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015116  Cdc42 binding domain-like
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021619  Mig-6 domain
 IPR030220  Activated CDC42 kinase 1
 IPR036028  SH3-like domain superfamily
 IPR037085  Cdc42 binding domain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070436 Grb2-EGFR complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005095 GTPase inhibitor activity TAS
 molecular_functionGO:0005154 epidermal growth factor receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050699 WW domain binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr