ENSG00000174292


Homo sapiens

Features
Gene ID: ENSG00000174292
  
Biological name :TNK1
  
Synonyms : Q13470 / TNK1 / tyrosine kinase non receptor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7380534
Gene end: 7389774
  
Corresponding Affymetrix probe sets: 205793_x_at (Human Genome U133 Plus 2.0 Array)   217149_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459799
Ensembl peptide - ENSP00000466590
Ensembl peptide - ENSP00000475164
Ensembl peptide - ENSP00000458834
Ensembl peptide - ENSP00000460146
NCBI entrez gene - 8711     See in Manteia.
OMIM - 608076
RefSeq - XM_011524048
RefSeq - NM_001251902
RefSeq - NM_003985
RefSeq - XM_011524045
RefSeq - XM_011524046
RefSeq - XM_011524047
RefSeq Peptide - NP_001238831
RefSeq Peptide - NP_003976
swissprot - U3KPR9
swissprot - I3L334
swissprot - Q13470
Ensembl - ENSG00000174292
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnk1ENSDARG00000069433Danio rerio
 Tnk1ENSMUSG00000001583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNK2 / Q07912 / tyrosine kinase non receptor 2ENSG0000006193839
ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4ENSG0000017856823
PTK2 / Q05397 / protein tyrosine kinase 2ENSG0000016939822
PTK2B / Q14289 / protein tyrosine kinase 2 betaENSG0000012089922
EGFR / P00533 / epidermal growth factor receptorENSG0000014664822
ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2ENSG0000014173621
ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3ENSG0000006536121
ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70ENSG0000011508518
SYK / P43405 / spleen associated tyrosine kinaseENSG0000016502517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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