ENSMUSG00000001583


Mus musculus

Features
Gene ID: ENSMUSG00000001583
  
Biological name :Tnk1
  
Synonyms : Non-receptor tyrosine-protein kinase TNK1 / Q99ML2 / Tnk1
  
Possible biological names infered from orthology : Q13470 / tyrosine kinase non receptor 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69851005
Gene end: 69858730
  
Corresponding Affymetrix probe sets: 10387668 (MoGene1.0st)   1422721_at (Mouse Genome 430 2.0 Array)   1425634_a_at (Mouse Genome 430 2.0 Array)   1425635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120585
Ensembl peptide - ENSMUSP00000001626
Ensembl peptide - ENSMUSP00000104266
Ensembl peptide - ENSMUSP00000104268
Ensembl peptide - ENSMUSP00000118490
NCBI entrez gene - 83813     See in Manteia.
MGI - MGI:1930958
RefSeq - NM_031880
RefSeq - XM_006534554
RefSeq Peptide - NP_114086
swissprot - Q99ML2
swissprot - Q5F2B4
swissprot - A2ARN2
swissprot - Q5F2B6
Ensembl - ENSMUSG00000001583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnk1ENSDARG00000069433Danio rerio
 TNK1ENSG00000174292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279140
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220922
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945622
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012221
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816621
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260721
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231221
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611718
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002732 trichoepithelioma "benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnk1tm1Sksuf/Tnk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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