ENSMUSG00000062312


Mus musculus

Features
Gene ID: ENSMUSG00000062312
  
Biological name :Erbb2
  
Synonyms : Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2
  
Possible biological names infered from orthology : erb-b2 receptor tyrosine kinase 2 / P04626
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98412470
Gene end: 98437716
  
Corresponding Affymetrix probe sets: 10380896 (MoGene1.0st)   1424919_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053897
NCBI entrez gene - 13866     See in Manteia.
MGI - MGI:95410
RefSeq - NM_001003817
RefSeq Peptide - NP_001003817
swissprot - P70424
Ensembl - ENSMUSG00000062312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erbb2ENSDARG00000026294Danio rerio
 ERBB2ENSGALG00000031529Gallus gallus
 ERBB2ENSG00000141736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012249
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220947
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816641
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260716
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945615
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279114
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145712
Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*ENSMUSG0000002611712
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0032886 regulation of microtubule-based process IEA
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IMP
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001042 RNA polymerase I core binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISS
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: (SJL/J-Slc9a1swe x B6.SJL-Slc9a1swe)F1

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm1Cbm/Erbb2+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bace1tm1Psa/Bace1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr6tm1Aki/Tlr6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000992 absent primary muscle spindle morphology "missing sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:23882]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000995 absent secondary muscle spindle "missing sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity" [What s wrong with my mouse?:ISBN 0-471-31639-3, J:23882]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0000996 partial loss of secondary muscle spindle "missing a portion of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity" [What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Gfra1tm3Jmi/Gfra1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001073 abnormal glossopharyngeal nerve morphology "malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001074 abnormal vagus nerve morphology "malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0001080 defasiculated phrenic nerve "misprojection or failure to bundle motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001082 abnormal geniculate ganglion morphology "malformed group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001084 abnormal petrosal ganglion morphology "malformation of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001107 reduced Schwann cell number "fewer than normal cells that sheath the axons of the peripheral nervous system" [J:29971]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Pten+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001633 poor circulation "insufficient movement of blood throughout the body" [MGI:cls, J:45302]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Mus81tm1Esse/Mus81tm1Esse
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Capgtm1Djk/Capgtm1Djk,Gsntm1Djk/Gsntm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama2tm1Eeng/Lama2tm1Eeng
Genetic Background: involves: 129S1/Sv * Black Swiss * FVB/N

Allelic Composition: Erbb2tm5(Erbb2)Mul/Erbb2tm5(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm6(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm5(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Mpz-cre)1Brn/0
Genetic Background: involves: FVB/N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Egr2tm2(cre)Pch/Egr2+,Erbb2tm1Cbm/Erbb2tm2Cbm
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004075 reduced Schwann cell precursor number "fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Erbb2tm3(Erbb2)Mul/Erbb2tm3(Erbb2)Mul,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Erbb2tm1Cbm/Erbb2+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Erbb2tm1Cbm/Erbb2+,Erbb3tm2Cbm/Erbb3+,Nrg1tm1Cbm/Nrg1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0008317 abnormal paravertebral ganglion morphology "any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm2Mul/Erbb2tm2Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli3Pdn/Gli3+
Genetic Background: involves: Jcl:ICR

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Erbb2tm1Haus/Erbb2tm1Klee,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009505 abnormal mammary gland lobule morphology "any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: (SJL/J-Slc9a1swe x B6.SJL-Slc9a1swe)F1

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: (SJL/J-Slc9a1swe x B6.SJL-Slc9a1swe)F1

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Pten+,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

Allelic Composition: Erbb2tm8(Erbb2)Mul/Erbb2+,Ptentm1Hwu/Ptentm1Hwu,Tg(MMTV-cre)7Mul/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N

 MP:0010493 abnormal atrium myocardium morphology "any structural anomaly of the atrial part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: En2tm2Alj/En2tm2Alj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Erbb2tm1Haus/Erbb2tm1Haus
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erbb2tm1Cbm/Erbb2tm2.1Cbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxc1tm1Blh/Foxc1tm1Blh,Foxc2tm1Blh/Foxc2tm1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Erbb2tm1Vrtn/Erbb2tm1Vrtn
Genetic Background: Not Specified

Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

Allelic Composition: Erbb2tm1Mul/Erbb2tm1Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: 129S5.B6(129S7)-Erbb2l11Jus8

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
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Allelic Composition: Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / reaction / complex
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / reaction / complex
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction / complex
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction / complex
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex / reaction
 ENSMUSG00000059495 Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*  / reaction / complex
 ENSMUSG00000026126 Ptpn18 / Q61152 / protein tyrosine phosphatase, non-receptor type 18 / Q99952*  / complex / reaction
 ENSMUSG00000041977 Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*  / reaction / complex
 ENSMUSG00000025373 Rnf41 / Q8BH75 / E3 ubiquitin-protein ligase NRDP1 / Q9H4P4* / ring finger protein 41*  / reaction / complex
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / reaction / complex






 

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