ENSMUSG00000059495


Mus musculus

Features
Gene ID: ENSMUSG00000059495
  
Biological name :Arhgef12
  
Synonyms : Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q8R4H2
  
Possible biological names infered from orthology : Q9NZN5 / Rho guanine nucleotide exchange factor 12
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 42963842
Gene end: 43107239
  
Corresponding Affymetrix probe sets: 10592655 (MoGene1.0st)   1423902_s_at (Mouse Genome 430 2.0 Array)   1446965_at (Mouse Genome 430 2.0 Array)   1451159_at (Mouse Genome 430 2.0 Array)   1453853_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072547
Ensembl peptide - ENSMUSP00000126598
Ensembl peptide - ENSMUSP00000150833
NCBI entrez gene - 69632     See in Manteia.
MGI - MGI:1916882
RefSeq - XM_017313567
RefSeq - XM_006510586
RefSeq - XM_011242597
RefSeq - XM_011242598
RefSeq - XM_017313565
RefSeq - XM_017313566
RefSeq - NM_001359232
RefSeq - NM_027144
RefSeq Peptide - NP_001346161
RefSeq Peptide - NP_081420
swissprot - F8VQN6
swissprot - Q8R4H2
swissprot - A0A1L1SUP5
Ensembl - ENSMUSG00000059495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef12aENSDARG00000030532Danio rerio
 arhgef12bENSDARG00000100913Danio rerio
 ARHGEF12ENSGALG00000006663Gallus gallus
 Q9NZN5ENSG00000196914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197731
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094023
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640617
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166216
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805911
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456810
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212158
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218957


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011702 abnormal fibroblast proliferation "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: m2Bei/m2Bei,Rgs4tm1Dgen/Rgs4+
Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / complex / reaction
 ENSMUSG00000021451 O09126 / Sema4d / Semaphorin-4D / Q92854*  / reaction / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction / complex
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / reaction / complex
 ENSMUSG00000002233 Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*  / reaction
 ENSMUSG00000054364 Rhob / P62746 / ras homolog family member B / P62745*  / reaction
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / reaction / complex






 

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