Manteia

ENSMUSG00000002233

Mus musculus

Features

Gene ID:	ENSMUSG00000002233

Biological name :	Rhoc

Synonyms :	Q62159 / Rhoc / Rho-related GTP-binding protein RhoC

Possible biological names infered from orthology :	P08134 / ras homolog family member C

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	F2.2
Gene start:	104788375
Gene end:	104794459

Corresponding Affymetrix probe sets:	10495054 (MoGene1.0st) 1435394_s_at (Mouse Genome 430 2.0 Array) 1448605_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000102399 Ensembl peptide - ENSMUSP00000142697 Ensembl peptide - ENSMUSP00000142855 Ensembl peptide - ENSMUSP00000002303 Ensembl peptide - ENSMUSP00000135659 NCBI entrez gene - 11853 See in Manteia. MGI - MGI:106028 RefSeq - NM_007484 RefSeq - NM_001291859 RefSeq Peptide - NP_001278788 RefSeq Peptide - NP_031510 swissprot - Q62159 swissprot - A0A0G2JEP8 swissprot - H3BL56 Ensembl - ENSMUSG00000002233

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rhoca	ENSDARG00000021309	Danio rerio
rhocb	ENSDARG00000018328	Danio rerio
RHOC	ENSGALG00000001569	Gallus gallus
RHOC	ENSG00000155366	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rhoa / Q9QUI0 / ras homolog family member A / P61586*	ENSMUSG00000007815	92
Rhob / P62746 / ras homolog family member B / P62745*	ENSMUSG00000054364	84
4930544G11Rik / RIKEN cDNA 4930544G11 gene	ENSMUSG00000036463	79
Rhod / P97348 / ras homolog family member D / O00212*	ENSMUSG00000041845	50
Rnd3 / P61588 / Rho-related GTP-binding protein RhoE / P61587* / Rho family GTPase 3*	ENSMUSG00000017144	49
Rhof / Q8BYP3 / ras homolog family member F (in filopodia) / Q9HBH0* / ras homolog family member F, filopodia associated*	ENSMUSG00000029449	48
Rnd2 / Q9QYM5 / Rho family GTPase 2 / P52198*	ENSMUSG00000001313	47
Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*	ENSMUSG00000054855	43

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR003578	Small GTPase superfamily, Rho type
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000281	mitotic cytokinesis	ISO
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0032464	positive regulation of protein homooligomerization	IMP
biological_process	GO:0043297	apical junction assembly	ISO
biological_process	GO:0044319	wound healing, spreading of cells	ISS
biological_process	GO:0060193	positive regulation of lipase activity	ISO
biological_process	GO:1902766	skeletal muscle satellite cell migration	ISS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0032154	cleavage furrow	ISO
cellular_component	GO:0032420	stereocilium	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	IEA

Pathways (from Reactome)

Pathway description

Rho GTPase cycle

G alpha (12/13) signalling events

Sema4D induced cell migration and growth-cone collapse

RHO GTPases activate PKNs

RHO GTPases activate CIT

RHO GTPases Activate ROCKs

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mtmr2^tm1Ueli/Mtmr2^tm1Ueli Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001273	decreased metastatic potential		Show Allelic Composition: Mtmr2^tm1Ueli/Mtmr2^tm1Ueli Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Mtmr2^tm1Ueli/Mtmr2^tm1Ueli Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000054855	Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*	/ reaction
ENSMUSG00000020886	Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*	/ reaction / complex
ENSMUSG00000036053	Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*	/ reaction / complex
ENSMUSG00000038943	Prc1 / Q99K43 / protein regulator of cytokinesis 1 / O43663*	/ reaction / complex
ENSMUSG00000023008	Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*	/ reaction / complex
ENSMUSG00000034930	Rtkn / Q8C6B2 / Rhotekin / Q9BST9*	/ reaction / complex
ENSMUSG00000062825	Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*	/ complex / reaction
ENSMUSG00000041498	Kif14 / L0N7N1 / Kinesin-like protein KIF14 / Q15058* / kinesin family member 14*	/ complex / reaction
ENSMUSG00000029580	Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*	/ complex / reaction
ENSMUSG00000057672	Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*	/ complex / reaction
ENSMUSG00000020580	Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*	/ reaction / complex
ENSMUSG00000021451	O09126 / Sema4d / Semaphorin-4D / Q92854*	/ reaction
ENSMUSG00000004591	Pkn2 / Q8BWW9 / Serine/threonine-protein kinase N2 / Q16513* / protein kinase N2*	/ complex / reaction
ENSMUSG00000041977	Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*	/ reaction
ENSMUSG00000024122	Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*	/ complex / reaction
ENSMUSG00000024290	Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*	/ reaction / complex
ENSMUSG00000062312	Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*	/ reaction
ENSMUSG00000053646	Plxnb1 / Q8CJH3 / plexin B1 / O43157*	/ reaction
ENSMUSG00000059495	Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr