Manteia

ENSMUSG00000023008

Mus musculus

Features

Gene ID:	ENSMUSG00000023008

Biological name :	Fmnl3

Synonyms :	Fmnl3 / Formin-like protein 3 / Q6ZPF4

Possible biological names infered from orthology :	formin like 3 / Q8IVF7

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	F1
Gene start:	99317225
Gene end:	99370482

Corresponding Affymetrix probe sets:	10432439 (MoGene1.0st) 1426825_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000079984 Ensembl peptide - ENSMUSP00000085566 Ensembl peptide - ENSMUSP00000113094 NCBI entrez gene - 22379 See in Manteia. MGI - MGI:109569 RefSeq - XM_006520846 RefSeq - NM_001310622 RefSeq - NM_001310623 RefSeq - NM_011711 RefSeq - XM_006520844 RefSeq Peptide - NP_001297552 RefSeq Peptide - NP_035841 RefSeq Peptide - NP_001297551 swissprot - Q6ZPF4 swissprot - D3Z7A7 Ensembl - ENSMUSG00000023008

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*	ENSMUSG00000036053	71
Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*	ENSMUSG00000055805	57
Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*	ENSMUSG00000034574	25
Daam2 / Q80U19 / Disheveled-associated activator of morphosis 2 / Q86T65* / dishevelled associated activator of morphogenesis 2*	ENSMUSG00000040260	24
3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*	ENSMUSG00000022021	23
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*	ENSMUSG00000034480	22
1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*	ENSMUSG00000024456	22
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*	ENSMUSG00000037679	21
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*	ENSMUSG00000041842	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR010472	Formin, FH3 domain
IPR010473	Formin, GTPase-binding domain
IPR011989	Armadillo-like helical
IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
IPR015425	Formin, FH2 domain
IPR016024	Armadillo-type fold
IPR027655	Formin-like protein 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0007010	cytoskeleton organization	ISO
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008360	regulation of cell shape	ISO
biological_process	GO:0016043	cellular component organization	IEA
biological_process	GO:0016477	cell migration	ISS
biological_process	GO:0030036	actin cytoskeleton organization	IEA
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017048	Rho GTPase binding	IEA
molecular_function	GO:0032794	GTPase activating protein binding	IDA

Pathways (from Reactome)

Pathway description

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0011239	abnormal skin coloration	"a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000002233	Rhoc / Q62159 / Rho-related GTP-binding protein RhoC / P08134* / ras homolog family member C*	/ reaction / complex
ENSMUSG00000029580	Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*	/ reaction / complex
ENSMUSG00000023008	Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*	/ complex
ENSMUSG00000062825	Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr