ENSMUSG00000040260


Mus musculus

Features
Gene ID: ENSMUSG00000040260
  
Biological name :Daam2
  
Synonyms : Daam2 / Disheveled-associated activator of morphosis 2 / Q80U19
  
Possible biological names infered from orthology : dishevelled associated activator of morphogenesis 2 / Q86T65
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 49456022
Gene end: 49564343
  
Corresponding Affymetrix probe sets: 10451679 (MoGene1.0st)   1430247_at (Mouse Genome 430 2.0 Array)   1455717_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052085
Ensembl peptide - ENSMUSP00000153095
NCBI entrez gene - 76441     See in Manteia.
MGI - MGI:1923691
RefSeq - XM_017317716
RefSeq - NM_001008231
RefSeq - XM_011246706
RefSeq - XM_011246707
RefSeq - XM_006525082
RefSeq - XM_006525083
RefSeq - XM_006525084
RefSeq - XM_006525085
RefSeq - XM_006525086
RefSeq - XM_006525087
RefSeq - XM_006525089
RefSeq - XM_006525090
RefSeq - XM_006525091
RefSeq Peptide - NP_001008232
swissprot - Q80U19
Ensembl - ENSMUSG00000040260
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 daam2ENSDARG00000028393Danio rerio
 DAAM2ENSGALG00000010055Gallus gallus
 DAAM2ENSG00000146122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Daam1 / Q8BPM0 / Disheveled-associated activator of morphosis 1 / Q9Y4D1* / dishevelled associated activator of morphogenesis 1*ENSMUSG0000003457465
1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*ENSMUSG0000002445626
3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*ENSMUSG0000002202124
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*ENSMUSG0000003448024
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*ENSMUSG0000003605323
Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*ENSMUSG0000005580523
Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*ENSMUSG0000002300822
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*ENSMUSG0000003767921
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*ENSMUSG0000004184213


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IDA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2000050 regulation of non-canonical Wnt signaling pathway IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Daam2tm1b(KOMP)Wtsi/Daam2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Daam2tm1b(KOMP)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004092 absent Z lines "missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004093 diffuse Z lines "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004146 absent M lines "missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0010759 decreased right ventricle systolic pressure "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0030566 abnormal A band morphology "any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0030567 abnormal I band morphology "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0030568 abnormal H zone morphology "any structural anomaly of the relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; it consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments; within the H zone is a thin dark M line, the attachment site for the thick filaments in the center of the sarcomere" [GO:0031673, https://en.wikipedia.org/wiki/Sarcomere]
Show

Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Daam2tm1Tpy/Daam2tm1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr