Manteia - Molecule gene

ENSMUSG00000034574

Mus musculus

Features

Gene ID:	ENSMUSG00000034574

Biological name :	Daam1

Synonyms :	Daam1 / Disheveled-associated activator of morphosis 1 / Q8BPM0

Possible biological names infered from orthology :	dishevelled associated activator of morphogenesis 1 / Q9Y4D1

Species:	Mus musculus

Chr. number:	12
Strand:	1
Band:	C3
Gene start:	71831078
Gene end:	71992333

Corresponding Affymetrix probe sets:	10396278 (MoGene1.0st) 1431035_at (Mouse Genome 430 2.0 Array) 1455244_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000082406 Ensembl peptide - ENSMUSP00000152532 Ensembl peptide - ENSMUSP00000152564 NCBI entrez gene - 208846 See in Manteia. MGI - MGI:1914596 RefSeq - XM_006515644 RefSeq - NM_001286452 RefSeq - NM_026102 RefSeq - NM_172464 RefSeq - XM_006515642 RefSeq - XM_006515643 RefSeq Peptide - NP_001273381 RefSeq Peptide - NP_080378 RefSeq Peptide - NP_766052 swissprot - Q8BPM0 Ensembl - ENSMUSG00000034574

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
daam1a	ENSDARG00000015059	Danio rerio
daam1b	ENSDARG00000009689	Danio rerio
DAAM1	ENSGALG00000012017	Gallus gallus
DAAM1	ENSG00000100592	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Daam2 / Q80U19 / Disheveled-associated activator of morphosis 2 / Q86T65* / dishevelled associated activator of morphogenesis 2*	ENSMUSG00000040260	67
1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*	ENSMUSG00000024456	28
2 / Diaph2 / O70566 / O60879* / diaphanous related formin 2*	ENSMUSG00000034480	26
3 / Diaph3 / Q9Z207 / Q9NSV4* / diaphanous related formin 3*	ENSMUSG00000022021	26
Fmnl1 / Q9JL26 / Formin-like protein 1 / O95466* / formin like 1*	ENSMUSG00000055805	25
Fmnl2 / A2APV2 / Formin-like protein 2 / Q96PY5* / formin like 2*	ENSMUSG00000036053	25
Fmnl3 / Q6ZPF4 / Formin-like protein 3 / Q8IVF7* / formin like 3*	ENSMUSG00000023008	24
Inf2 / inverted formin, FH2 and WH2 domain containing / Q27J81*	ENSMUSG00000037679	22
Fhdc1 / Q3ULZ2 / FH2 domain-containing protein 1 / Q9C0D6* / FH2 domain containing 1*	ENSMUSG00000041842	13

Protein motifs (from Interpro)

Interpro ID	Name
IPR010472	Formin, FH3 domain
IPR010473	Formin, GTPase-binding domain
IPR011989	Armadillo-like helical
IPR014767	Diaphanous autoregulatory (DAD) domain
IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
IPR015425	Formin, FH2 domain
IPR016024	Armadillo-type fold
IPR027650	Disheveled-associated activator of morphogenesis 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0016043	cellular component organization	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0030036	actin cytoskeleton organization	IEA
cellular_component	GO:0001725	stress fiber	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0031514	motile cilium	ISO
cellular_component	GO:0036064	ciliary basal body	ISO
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017048	Rho GTPase binding	IEA
molecular_function	GO:0042802	identical protein binding	ISO

Pathways (from Reactome)

Pathway description

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0001792	impaired wound healing	"reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0002106	abnormal muscle physiology	"anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0002189	abnormal myocardial trabeculae morphology	"malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 Genetic Background: involves: C57BL/6J * CD-1 Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0002740	heart hypoplasia	"decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003547	abnormal pulmonary pressure	"altered tension of the blood within the pulmonary arteries" [J:54986, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003566	abnormal cell adhesion	"altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0003822	decreased left ventricle systolic pressure	"decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003920	abnormal right ventricle morphology	"structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004009	abnormal diastolic filling velocity	"anomaly in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:Rat Genome Database submission]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004056	abnormal myocardial compact layer morphology	"malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004090	abnormal sarcomere morphology	"any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0004092	absent Z lines	"missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004093	diffuse Z lines	"widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004146	absent M lines	"missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0004215	abnormal myocardial fiber physiology	"anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0005294	abnormal heart ventricle morphology	"structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0005312	pericardial effusion	"escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0006267	abnormal intercalated disc morphology	"any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0008788	abnormal fetal cardiomyocyte morphology	"any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0010556	thin ventricle myocardium compact layer	"reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0010630	abnormal cardiac muscle tissue morphology	"any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0010759	decreased right ventricle systolic pressure	"decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a^tm1Amc Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0013279	increased fasted circulating glucose level	"increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0013294	prenatal lethality prior to heart atrial septation	"death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]	Show Allelic Composition: Cyp27b1^{tm1b(EUCOMM)Hmgu}/Cyp27b1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Cyp27b1^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0020414	abnormal fibroblast physiology	"any functional anomaly in the cellular physiological processes carried out by a fibroblast cell population" [mgi:anna]	Show Allelic Composition: Ripply3^tm1Sjt/Ripply3⁺,Tbx1^tm1Bem/Tbx1⁺ Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6J * SJL
MP:0030564	thick myocardium compact layer	"increased thickness of the outer, dense layer of the myocardium" [MGI:anna, PMID:26526197]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺,Wnt5a^tm1Amc/Wnt5a⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0030566	abnormal A band morphology	"any structural anomaly of the dark-staining region of a sarcomere that is situated between two I bands and marked by partial overlapping of thin (actin) and thick (myosin) filaments; an A band is anisotropic to polarized light and contains the entire length of a single thick filament; its center is traversed by the paler H zone, which in turn contains the M line" [GO:0031672, https://en.wikipedia.org/wiki/Sarcomere, https://medical-dictionary.thefreedictionary.com/A+band]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0030567	abnormal I band morphology	"any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd
MP:0030568	abnormal H zone morphology	"any structural anomaly of the relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; it consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments; within the H zone is a thin dark M line, the attachment site for the thick filaments in the center of the sarcomere" [GO:0031673, https://en.wikipedia.org/wiki/Sarcomere]	Show Allelic Composition: Daam1^tm1.1Tpy/Daam1^tm1.1Tpy,Daam2^tm1Tpy/Daam2^tm1Tpy,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020888	Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*	/ complex / reaction
ENSMUSG00000018293	Pfn1 / P62962 / profilin 1 / P07737*	/ complex / reaction
ENSMUSG00000007815	Rhoa / Q9QUI0 / ras homolog family member A / P61586*	/ complex / reaction

1 s.

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