ENSG00000100592


Homo sapiens

Features
Gene ID: ENSG00000100592
  
Biological name :DAAM1
  
Synonyms : DAAM1 / dishevelled associated activator of morphogenesis 1 / Q9Y4D1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.1
Gene start: 59188646
Gene end: 59371405
  
Corresponding Affymetrix probe sets: 1555989_at (Human Genome U133 Plus 2.0 Array)   216060_s_at (Human Genome U133 Plus 2.0 Array)   226666_at (Human Genome U133 Plus 2.0 Array)   232552_at (Human Genome U133 Plus 2.0 Array)   244062_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354162
Ensembl peptide - ENSP00000378557
Ensembl peptide - ENSP00000450498
NCBI entrez gene - 23002     See in Manteia.
OMIM - 606626
RefSeq - XM_005267431
RefSeq - NM_001270520
RefSeq - NM_014992
RefSeq - XM_005267430
RefSeq Peptide - NP_055807
RefSeq Peptide - NP_001257449
swissprot - Q9Y4D1
swissprot - G3V275
Ensembl - ENSG00000100592
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 daam1aENSDARG00000015059Danio rerio
 daam1bENSDARG00000009689Danio rerio
 DAAM1ENSGALG00000012017Gallus gallus
 Daam1ENSMUSG00000034574Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAAM2 / Q86T65 / dishevelled associated activator of morphogenesis 2ENSG0000014612268
DIAPH1 / O60610 / diaphanous related formin 1ENSG0000013150429
DIAPH2 / O60879 / diaphanous related formin 2ENSG0000014720227
DIAPH3 / Q9NSV4 / diaphanous related formin 3ENSG0000013973426
FMNL2 / Q96PY5 / formin like 2ENSG0000015782725
FMNL1 / O95466 / formin like 1ENSG0000018492225
FMNL3 / Q8IVF7 / formin like 3ENSG0000016179123
INF2 / Q27J81 / inverted formin, FH2 and WH2 domain containingENSG0000020348523
FHDC1 / Q9C0D6 / FH2 domain containing 1ENSG0000013746013


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027650  Disheveled-associated activator of morphogenesis 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
PCP/CE pathway
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction / complex
 ENSG00000108518 PFN1 / P07737 / profilin 1  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction






 

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