ENSG00000157827


Homo sapiens

Features
Gene ID: ENSG00000157827
  
Biological name :FMNL2
  
Synonyms : FMNL2 / formin like 2 / Q96PY5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q23.3
Gene start: 152335237
Gene end: 152649834
  
Corresponding Affymetrix probe sets: 226184_at (Human Genome U133 Plus 2.0 Array)   235881_at (Human Genome U133 Plus 2.0 Array)   242665_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418959
Ensembl peptide - ENSP00000288670
NCBI entrez gene - 114793     See in Manteia.
OMIM - 616285
RefSeq - XM_011510536
RefSeq - NM_052905
RefSeq - XM_011510533
RefSeq - XM_011510534
RefSeq - XM_011510535
RefSeq - XM_005246263
RefSeq - XM_005246265
RefSeq - XM_011510530
RefSeq - XM_011510531
RefSeq - XM_011510532
RefSeq Peptide - NP_443137
swissprot - Q96PY5
swissprot - C9IZY8
Ensembl - ENSG00000157827
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fmnl2aENSDARG00000012586Danio rerio
 fmnl2bENSDARG00000075041Danio rerio
 FMNL2ENSGALG00000012525Gallus gallus
 Fmnl2ENSMUSG00000036053Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FMNL3 / Q8IVF7 / formin like 3ENSG0000016179166
FMNL1 / O95466 / formin like 1ENSG0000018492259
DAAM1 / Q9Y4D1 / dishevelled associated activator of morphogenesis 1ENSG0000010059225
DAAM2 / Q86T65 / dishevelled associated activator of morphogenesis 2ENSG0000014612223
DIAPH3 / Q9NSV4 / diaphanous related formin 3ENSG0000013973422
DIAPH2 / O60879 / diaphanous related formin 2ENSG0000014720221
DIAPH1 / O60610 / diaphanous related formin 1ENSG0000013150421
INF2 / Q27J81 / inverted formin, FH2 and WH2 domain containingENSG0000020348520
FHDC1 / Q9C0D6 / FH2 domain containing 1ENSG0000013746013


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR017987  Wilm"s tumour protein
 IPR027656  Formin-like protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0022604 regulation of cell morphogenesis IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction / complex
 ENSG00000157827 FMNL2 / Q96PY5 / formin like 2  / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex






 

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