ENSG00000161791


Homo sapiens

Features
Gene ID: ENSG00000161791
  
Biological name :FMNL3
  
Synonyms : FMNL3 / formin like 3 / Q8IVF7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 49636499
Gene end: 49708165
  
Corresponding Affymetrix probe sets: 227844_at (Human Genome U133 Plus 2.0 Array)   230640_at (Human Genome U133 Plus 2.0 Array)   232249_at (Human Genome U133 Plus 2.0 Array)   238823_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000335655
Ensembl peptide - ENSP00000344311
Ensembl peptide - ENSP00000447479
Ensembl peptide - ENSP00000448939
NCBI entrez gene - 91010     See in Manteia.
OMIM - 616288
RefSeq - XM_011538974
RefSeq - XM_011538969
RefSeq - XM_011538970
RefSeq - XM_011538971
RefSeq - XM_011538972
RefSeq - XM_011538973
RefSeq - NM_175736
RefSeq - NM_198900
RefSeq - XM_005269218
RefSeq - XM_011538968
RefSeq Peptide - NP_783863
RefSeq Peptide - NP_944489
swissprot - F8W1F5
swissprot - Q8IVF7
swissprot - F8VYL1
Ensembl - ENSG00000161791
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fmnl3ENSDARG00000004372Danio rerio
 Fmnl3ENSMUSG00000023008Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FMNL2 / Q96PY5 / formin like 2ENSG0000015782770
FMNL1 / O95466 / formin like 1ENSG0000018492258
DAAM1 / Q9Y4D1 / dishevelled associated activator of morphogenesis 1ENSG0000010059225
DAAM2 / Q86T65 / dishevelled associated activator of morphogenesis 2ENSG0000014612224
DIAPH1 / O60610 / diaphanous related formin 1ENSG0000013150423
DIAPH3 / Q9NSV4 / diaphanous related formin 3ENSG0000013973422
INF2 / Q27J81 / inverted formin, FH2 and WH2 domain containingENSG0000020348521
DIAPH2 / O60879 / diaphanous related formin 2ENSG0000014720221
FHDC1 / Q9C0D6 / FH2 domain containing 1ENSG0000013746014


Protein motifs (from Interpro)
Interpro ID Name
 IPR010472  Formin, FH3 domain
 IPR010473  Formin, GTPase-binding domain
 IPR011989  Armadillo-like helical
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027655  Formin-like protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016043 cellular component organization IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding ISS


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000161791 FMNL3 / Q8IVF7 / formin like 3  / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction






 

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