Manteia

ENSDARG00000004372

Danio rerio

Features

Gene ID:	ENSDARG00000004372

Biological name :	fmnl3

Synonyms :	fmnl3 / formin-like 3 / Q6NXC0

Possible biological names infered from orthology :	Formin-like protein 3 / Q6ZPF4 / Q8IVF7

Species:	Danio rerio

Chr. number:	23
Strand:	1
Band:
Gene start:	25354856
Gene end:	25448872

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000099869 Ensembl peptide - ENSDARP00000113078 Ensembl peptide - ENSDARP00000115552 NCBI entrez gene - 407694 See in Manteia. RefSeq - NM_001346154 RefSeq Peptide - NP_001333083 swissprot - F1R067 swissprot - E9QG32 swissprot - F1R4P0 swissprot - Q6NXC0 ZFIN ID - ZDB-GENE-030131-1571 Ensembl - ENSDARG00000004372

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
FMNL3	ENSG00000161791	Homo sapiens
Fmnl3	ENSMUSG00000023008	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
fmnl2a / formin-like 2a / FMNL2* / A2APV2* / Q96PY5* / formin like 2* / Formin-like protein 2 *	ENSDARG00000012586	68
fmnl2b / formin-like 2b / FMNL2* / A2APV2* / Q96PY5* / formin like 2* / Formin-like protein 2 *	ENSDARG00000075041	68
fmnl1a / formin-like 1a / FMNL1* / O95466* / Q9JL26* / formin like 1* / Formin-like protein 1 *	ENSDARG00000055713	53
daam1b / dishevelled associated activator of morphogenesis 1b / DAAM1* / Q8BPM0* / Q9Y4D1* / Disheveled-associated activator of morphosis 1 * / dishevelled associated activator of morphogenesis 1*	ENSDARG00000009689	24
daam1a / dishevelled associated activator of morphogenesis 1a / DAAM1* / Q8BPM0* / Q9Y4D1* / Disheveled-associated activator of morphosis 1 * / dishevelled associated activator of morphogenesis 1*	ENSDARG00000015059	24
CABZ01055365.1 / FMNL1* / O95466* / formin like 1*	ENSDARG00000104263	23
daam2 / dishevelled associated activator of morphogenesis 2 / Q80U19* / Q86T65* / Disheveled-associated activator of morphosis 2 *	ENSDARG00000028393	23
diaph2 / diaphanous-related formin 2 / 2 * / O60879* / O70566*	ENSDARG00000076060	21
diaph3 / diaphanous-related formin 3 / 3 * / Q9NSV4* / Q9Z207*	ENSDARG00000090785	21
fhdc1 / FH2 domain containing 1 / Q3ULZ2* / Q9C0D6* / FH2 domain-containing protein 1 *	ENSDARG00000074812	12
fhdc2 / FH2 domain containing 2	ENSDARG00000099767	11
fhdc3 / FH2 domain containing 3	ENSDARG00000069129	10
fhdc4 / FH2 domain containing 4	ENSDARG00000086261	10
fhdc5 / FH2 domain containing 5 / FHDC1* / Q3ULZ2* / Q9C0D6* / FH2 domain containing 1* / FH2 domain-containing protein 1 *	ENSDARG00000095962	8
CABZ01057928.1 / DIAPH1* / O60610* / diaphanous related formin 1*	ENSDARG00000115082	7
CABZ01060373.1 / INF2* / Q27J81* / inverted formin, FH2 and WH2 domain containing*	ENSDARG00000117069	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR010472	Formin, FH3 domain
IPR010473	Formin, GTPase-binding domain
IPR011989	Armadillo-like helical
IPR014767	Diaphanous autoregulatory (DAD) domain
IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
IPR015425	Formin, FH2 domain
IPR016024	Armadillo-type fold
IPR027655	Formin-like protein 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0002040	sprouting angiogenesis	IMP
biological_process	GO:0007010	cytoskeleton organization	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008360	regulation of cell shape	IEA
biological_process	GO:0016043	cellular component organization	IEA
biological_process	GO:0016477	cell migration	IEA
biological_process	GO:0030036	actin cytoskeleton organization	IEA
biological_process	GO:0030041	actin filament polymerization	IDA
biological_process	GO:0046847	filopodium assembly	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0017048	Rho GTPase binding	IEA

Pathways (from Reactome)

Pathway description

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000037	anatomical structure	anatomical structure decreased distribution , abnormal	Show
ZFA:0001285	intersegmental vessel	intersegmental vessel decreased length , abnormal intersegmental vessel disorganized , abnormal intersegmental vessel decreased amount , abnormal	Show
ZFA:0001286	caudal vein plexus	caudal vein plexus decreased width , abnormal caudal vein plexus malformed , abnormal caudal vein plexus sprouting angiogenesis process quality , abnormal caudal vein plexus angiogenic sprout decreased amount , abnormal caudal vein plexus blood vessel endothelial cell has fewer parts of type blood vessel endothelial cell filopodium, abnormal	Show
ZFA:0005025	dorsal longitudinal anastomotic vessel	dorsal longitudinal anastomotic vessel aplastic , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000018328	rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *	/ complex / reaction
ENSDARG00000021309	rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *	/ reaction / complex
ENSDARG00000037746	actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...	/ reaction / complex
ENSDARG00000037870	actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...	/ complex / reaction
ENSDARG00000004372	fmnl3 / Q6NXC0 / formin-like 3 / Q8IVF7* / Q6ZPF4* / Formin-like protein 3 *	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr