ENSDARG00000018328


Danio rerio

Features
Gene ID: ENSDARG00000018328
  
Biological name :rhocb
  
Synonyms : Q6DHE8 / ras homolog family member Cb / rhocb
  
Possible biological names infered from orthology : P08134 / Q62159 / ras homolog family member C / RHOC / Rho-related GTP-binding protein RhoC
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 27555314
Gene end: 27624329
  
Corresponding Affymetrix probe sets: Dr.15949.2.S1_a_at (Zebrafish Array)   Dr.15949.3.S1_at (Zebrafish Array)   Dr.15949.3.S1_a_at (Zebrafish Array)   NM_001002445_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000121216
Ensembl peptide - ENSDARP00000002761
NCBI entrez gene - 436718     See in Manteia.
RefSeq - NM_001002445
RefSeq Peptide - NP_001002445
swissprot - B0R1F6
swissprot - Q6DHE8
ZFIN ID - ZDB-GENE-040718-144
Ensembl - ENSDARG00000018328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOCENSGALG00000001569Gallus gallus
 RHOCENSG00000155366Homo sapiens
 RhocENSMUSG00000002233Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *ENSDARG0000002130996
rhoac / Q7T2E8 / ras homolog gene family, member AcENSDARG0000011605896
rhoaa / Q6NUX8 / ras homolog gene family, member AaENSDARG0000002684594
rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*ENSDARG0000009467393
rnd3b / Rho family GTPase 3b / RND3* / P61588* / P61587* / Rho family GTPase 3* / Rho-related GTP-binding protein RhoE *ENSDARG0000000739650
rnd3a / Rho family GTPase 3a / RND3* / P61588* / P61587* / Rho family GTPase 3* / Rho-related GTP-binding protein RhoE *ENSDARG0000007679948
rhof / ras homolog family member F / Q9HBH0* / Q8BYP3* / ras homolog family member F (in filopodia)* / ras homolog family member F, filopodia associated*ENSDARG0000005438947
rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *ENSDARG0000000421846
rnd2 / Rho family GTPase 2 / P52198* / Q9QYM5*ENSDARG0000007073545
rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *ENSDARG0000003054745


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:1902766 skeletal muscle satellite cell migration ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000092 axis axis decreased length , abnormal
Show

 ZFA:0000135 notochord notochord decreased length , abnormal
notochord increased width , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018285 pdpk1b / 3-phosphoinositide dependent protein kinase 1b / PDPK1* / O15530* / Q9Z2A0* / 3-phosphoinositide dependent protein kinase 1*  / reaction / complex
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / reaction
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / reaction / complex
 ENSDARG00000101293 zgc:153916 / PKN2 (1 of many) / PKN2* / Q16513* / protein kinase N2*  / reaction / complex
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / reaction / complex
 ENSDARG00000101983 pkn2 / protein kinase N2 / Q16513*  / reaction / complex
 ENSDARG00000062187 kif14 / kinesin family member 14 / L0N7N1* / Q15058* / Kinesin-like protein KIF14 *  / reaction / complex
 ENSDARG00000004372 fmnl3 / Q6NXC0 / formin-like 3 / Q8IVF7* / Q6ZPF4* / Formin-like protein 3 *  / reaction / complex
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / reaction
 ENSDARG00000030532 arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*  / reaction
 ENSDARG00000100918 prc1a / protein regulator of cytokinesis 1a / PRC1* / O43663* / protein regulator of cytokinesis 1*  / reaction / complex
 ENSDARG00000100913 arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...  / reaction
 ENSDARG00000058993 rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*  / complex / reaction






 

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