ENSGALG00000001569


Gallus gallus

Features
Gene ID: ENSGALG00000001569
  
Biological name :RHOC
  
Synonyms : Q9PSX7 / RHOC / Rho-related GTP-binding protein RhoC
  
Possible biological names infered from orthology : P08134 / Q62159 / ras homolog family member C
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 3550497
Gene end: 3556153
  
Corresponding Affymetrix probe sets: Gga.17535.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002383
NCBI entrez gene - 395869     See in Manteia.
RefSeq - NM_001029849
RefSeq Peptide - NP_001025020
swissprot - Q9PSX7
Ensembl - ENSGALG00000001569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhocaENSDARG00000021309Danio rerio
 rhocbENSDARG00000018328Danio rerio
 RHOCENSG00000155366Homo sapiens
 RhocENSMUSG00000002233Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOA / ras homolog family member A / P61586* / 4930544G11Rik* / RIKEN cDNA 4930544G11 gene*ENSGALG0000000380687
RHOB / ras homolog family member B / P62745* / P62746*ENSGALG0000001648585
RHOF / ras homolog family member F, filopodia associated / Q8BYP3* / Q9HBH0* / ras homolog family member F (in filopodia)*ENSGALG0000003972451
RND2 / Rho family GTPase 2 / P52198* / Q9QYM5*ENSGALG0000000280448
RND3 / Rho family GTPase 3 / P61587* / P61588* / Rho-related GTP-binding protein RhoE *ENSGALG0000002631348
ENSGALG0000004477441


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0043297 apical junction assembly IEA
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0060193 positive regulation of lipase activity IEA
 biological_processGO:1902766 skeletal muscle satellite cell migration ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032154 cleavage furrow ISS
 cellular_componentGO:0032420 stereocilium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012525 FMNL2 / formin like 2 / A2APV2* / Q96PY5* / Formin-like protein 2 *  / complex / reaction
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / complex / reaction
 ENSGALG00000016451 ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction / complex
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction / complex
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / reaction
 ENSGALG00000006663 ARHGEF12 / Rho guanine nucleotide exchange factor 12 / Q8R4H2* / Q9NZN5* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction






 

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