ENSGALG00000006526


Gallus gallus

Features
Gene ID: ENSGALG00000006526
  
Biological name :PLXNB1
  
Synonyms : plexin B1 / PLXNB1
  
Possible biological names infered from orthology : O43157 / Q8CJH3
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 11332373
Gene end: 11363615
  
Corresponding Affymetrix probe sets: GgaAffx.21968.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010536
NCBI entrez gene - 100859325     See in Manteia.
RefSeq - XM_015292930
RefSeq - NM_001257265
RefSeq - XM_015292928
RefSeq - XM_015292929
RefSeq Peptide - NP_001244194
swissprot - E1BWU6
Ensembl - ENSGALG00000006526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb1aENSDARG00000075821Danio rerio
 plxnb1bENSDARG00000017211Danio rerio
 O43157ENSG00000164050Homo sapiens
 Plxnb1ENSMUSG00000053646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXNB2 / plexin B2 / B2RXS4* / O15031*ENSGALG0000003986141
PLXNA2 / plexin A2 / O75051* / P70207*ENSGALG0000000126434
PLXNA1 / plexin A1 / P70206* / Q9UIW2*ENSGALG0000000609734
PLXNA4 / plexin A4 / Q80UG2* / Q9HCM2*ENSGALG0000000647334
PLXND1 / plexin D1 / Q3UH93* / Q9Y4D7*ENSGALG0000000847332
PLXNC1 / plexin C1 / O60486* / Q9QZC2*ENSGALG0000001130919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043931 ossification involved in bone maturation IEA
 biological_processGO:0048675 axon extension IBA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IEA
 cellular_componentGO:0002116 semaphorin receptor complex IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0017154 semaphorin receptor activity IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / reaction
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / reaction / complex
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / reaction
 ENSGALG00000006663 ARHGEF12 / Rho guanine nucleotide exchange factor 12 / Q8R4H2* / Q9NZN5* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000036028 GNA13 / G protein subunit alpha 13 / P27601* / Q14344* / guanine nucleotide binding protein, alpha 13*  / complex / reaction






 

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