ENSG00000164050


Homo sapiens

Features
Gene ID: ENSG00000164050
  
Biological name :PLXNB1
  
Synonyms : O43157 / plexin B1 / PLXNB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 48403854
Gene end: 48430051
  
Corresponding Affymetrix probe sets: 215668_s_at (Human Genome U133 Plus 2.0 Array)   215807_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296440
Ensembl peptide - ENSP00000351338
Ensembl peptide - ENSP00000395987
Ensembl peptide - ENSP00000414199
NCBI entrez gene - 5364     See in Manteia.
OMIM - 601053
RefSeq - XM_017006631
RefSeq - NM_001130082
RefSeq - NM_002673
RefSeq - XM_011533836
RefSeq - XM_011533837
RefSeq - XM_017006630
RefSeq - XM_011533833
RefSeq - XM_011533834
RefSeq - XM_011533835
RefSeq Peptide - NP_002664
RefSeq Peptide - NP_001123554
swissprot - O43157
Ensembl - ENSG00000164050
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plxnb1aENSDARG00000075821Danio rerio
 plxnb1bENSDARG00000017211Danio rerio
 PLXNB1ENSGALG00000006526Gallus gallus
 Plxnb1ENSMUSG00000053646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLXNB3 / Q9ULL4 / plexin B3ENSG0000019875346
O15031 / PLXNB2 / plexin B2ENSG0000019657638
PLXNA1 / Q9UIW2 / plexin A1ENSG0000011455432
O75051 / PLXNA2 / plexin A2ENSG0000007635631
PLXND1 / Q9Y4D7 / plexin D1ENSG0000000439931
PLXNA4 / Q9HCM2 / plexin A4ENSG0000022186630
P51805 / PLXNA3 / plexin A3ENSG0000013082730
O60486 / PLXNC1 / plexin C1ENSG0000013604020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR002909  IPT domain
 IPR008936  Rho GTPase activation protein
 IPR013548  Plexin, cytoplasmic RasGAP domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR031148  Plexin family
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016477 cell migration NAS
 biological_processGO:0033689 negative regulation of osteoblast proliferation ISS
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0043931 ossification involved in bone maturation ISS
 biological_processGO:0048675 axon extension IBA
 biological_processGO:0048812 neuron projection morphogenesis ISS
 biological_processGO:0050772 positive regulation of axonogenesis IBA
 biological_processGO:0051493 regulation of cytoskeleton organization IDA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IDA
 biological_processGO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis ISS
 cellular_componentGO:0002116 semaphorin receptor complex IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017154 semaphorin receptor activity TAS
 molecular_functionGO:0030215 semaphorin receptor binding TAS
 molecular_functionGO:0032794 GTPase activating protein binding ISS


Pathways (from Reactome)
Pathway description
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132694 O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11  / reaction / complex
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / complex / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / reaction / complex
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / reaction / complex
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / reaction / complex
 ENSG00000126458 RRAS / P10301 / RAS related  / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000160007 Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex






 

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