ENSG00000132694


Homo sapiens

Features
Gene ID: ENSG00000132694
  
Biological name :ARHGEF11
  
Synonyms : ARHGEF11 / O15085 / Rho guanine nucleotide exchange factor 11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.1
Gene start: 156934840
Gene end: 157045370
  
Corresponding Affymetrix probe sets: 202913_at (Human Genome U133 Plus 2.0 Array)   202914_s_at (Human Genome U133 Plus 2.0 Array)   238730_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354644
Ensembl peptide - ENSP00000357177
NCBI entrez gene - 9826     See in Manteia.
OMIM - 605708
RefSeq - XM_017002924
RefSeq - NM_014784
RefSeq - NM_198236
RefSeq - XM_017002921
RefSeq - XM_017002922
RefSeq - XM_017002923
RefSeq - XM_005245629
RefSeq - XM_005245633
RefSeq - XM_006711659
RefSeq - XM_006711660
RefSeq - XM_006711661
RefSeq - XM_006711662
RefSeq - XM_006711663
RefSeq - XM_006711665
RefSeq - XM_011510185
RefSeq - XM_011510186
RefSeq - XM_011510187
RefSeq - XM_017002920
RefSeq Peptide - NP_937879
RefSeq Peptide - NP_055599
swissprot - O15085
Ensembl - ENSG00000132694
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef11ENSDARG00000052482Danio rerio
 ARHGEF11ENSGALG00000039163Gallus gallus
 Arhgef11ENSMUSG00000041977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691432
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692820
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494416
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077615
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488012
AC008878.3ENSG0000026886112
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658411
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG000001738488
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG000001639477


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR016137  RGS domain
 IPR032919  Rho guanine nucleotide exchange factor 11
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0006941 striated muscle contraction NAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0030010 establishment of cell polarity NAS
 biological_processGO:0030036 actin cytoskeleton organization NAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / complex / reaction
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction






 

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