ENSG00000170776


Homo sapiens

Features
Gene ID: ENSG00000170776
  
Biological name :AKAP13
  
Synonyms : AKAP13 / A-kinase anchoring protein 13 / Q12802
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.3
Gene start: 85380571
Gene end: 85749358
  
Corresponding Affymetrix probe sets: 208325_s_at (Human Genome U133 Plus 2.0 Array)   209534_x_at (Human Genome U133 Plus 2.0 Array)   213516_at (Human Genome U133 Plus 2.0 Array)   221718_s_at (Human Genome U133 Plus 2.0 Array)   222023_at (Human Genome U133 Plus 2.0 Array)   222024_s_at (Human Genome U133 Plus 2.0 Array)   224884_at (Human Genome U133 Plus 2.0 Array)   227039_at (Human Genome U133 Plus 2.0 Array)   229783_at (Human Genome U133 Plus 2.0 Array)   232188_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453620
Ensembl peptide - ENSP00000483091
Ensembl peptide - ENSP00000482058
Ensembl peptide - ENSP00000481485
Ensembl peptide - ENSP00000480789
Ensembl peptide - ENSP00000477780
Ensembl peptide - ENSP00000453768
Ensembl peptide - ENSP00000453634
Ensembl peptide - ENSP00000354718
Ensembl peptide - ENSP00000378018
Ensembl peptide - ENSP00000378026
Ensembl peptide - ENSP00000452622
Ensembl peptide - ENSP00000452698
Ensembl peptide - ENSP00000453205
NCBI entrez gene - 11214     See in Manteia.
OMIM - 604686
RefSeq - NM_006738
RefSeq - NM_007200
RefSeq - NM_001270546
RefSeq Peptide - NP_001257475
RefSeq Peptide - NP_006729
RefSeq Peptide - NP_009131
swissprot - H0YK84
swissprot - H0YLH1
swissprot - H0YMI5
swissprot - H0YMW2
swissprot - A8MYJ1
swissprot - Q12802
swissprot - A0A087X047
swissprot - A0A087WYS7
swissprot - A0A087WY36
swissprot - A0A087WX73
swissprot - A0A087WTD7
swissprot - H0YK18
Ensembl - ENSG00000170776
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP13ENSDARG00000079994Danio rerio
 si:dkey-172h23.2ENSDARG00000023868Danio rerio
 AKAP13ENSGALG00000006840Gallus gallus
 Akap13ENSMUSG00000066406Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494419
AC008878.3ENSG0000026886114
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488014
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658414
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691410
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG000001326949
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG000000769286
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG000001639474
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG000001738484


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR018459  RII binding domain
 IPR028852  A-kinase anchor protein 13
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007507 heart development ISS
 biological_processGO:0010611 regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051168 nuclear export IEA
 biological_processGO:0055007 cardiac muscle cell differentiation ISS
 biological_processGO:0060297 regulation of sarcomere organization ISS
 biological_processGO:0060348 bone development ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IMP
 biological_processGO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISS
 biological_processGO:1900169 regulation of glucocorticoid mediated signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005078 MAP-kinase scaffold activity IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051018 protein kinase A binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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