ENSG00000214944


Homo sapiens

Features
Gene ID: ENSG00000214944
  
Biological name :ARHGEF28
  
Synonyms : ARHGEF28 / Q8N1W1 / Rho guanine nucleotide exchange factor 28
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.2
Gene start: 73626158
Gene end: 73941993
  
Corresponding Affymetrix probe sets: 1554003_at (Human Genome U133 Plus 2.0 Array)   1554004_a_at (Human Genome U133 Plus 2.0 Array)   1559706_at (Human Genome U133 Plus 2.0 Array)   1560348_at (Human Genome U133 Plus 2.0 Array)   219610_at (Human Genome U133 Plus 2.0 Array)   232994_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421859
Ensembl peptide - ENSP00000421081
Ensembl peptide - ENSP00000441436
Ensembl peptide - ENSP00000441913
Ensembl peptide - ENSP00000296794
Ensembl peptide - ENSP00000296799
Ensembl peptide - ENSP00000411459
Ensembl peptide - ENSP00000412175
NCBI entrez gene - 64283     See in Manteia.
OMIM - 612790
RefSeq - XM_017009703
RefSeq - NM_001177693
RefSeq - NM_001244364
RefSeq - XM_005248568
RefSeq - XM_011543546
RefSeq - XM_011543547
RefSeq - XM_017009702
RefSeq - NM_001080479
RefSeq Peptide - NP_001231293
RefSeq Peptide - NP_001073948
RefSeq Peptide - NP_001171164
swissprot - D6RGZ3
swissprot - Q8N1W1
swissprot - D6RAP0
Ensembl - ENSG00000214944
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef28ENSDARG00000060415Danio rerio
 si:ch211-272b8.6ENSDARG00000091607Danio rerio
 ARHGEF28ENSGALG00000014923Gallus gallus
 Arhgef28ENSMUSG00000021662Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077631
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488026
AC008878.3ENSG0000026886125
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658419
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691414
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269414
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692810
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG000001738486
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG000001639476


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity EXP
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction






 

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