ENSG00000108947


Homo sapiens

Features
Gene ID: ENSG00000108947
  
Biological name :EFNB3
  
Synonyms : EFNB3 / ephrin B3 / Q15768
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7705202
Gene end: 7711378
  
Corresponding Affymetrix probe sets: 205031_at (Human Genome U133 Plus 2.0 Array)   210883_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226091
NCBI entrez gene - 1949     See in Manteia.
OMIM - 602297
RefSeq - NM_001406
RefSeq Peptide - NP_001397
swissprot - Q15768
Ensembl - ENSG00000108947
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb3aENSDARG00000112993Danio rerio
 efnb3bENSDARG00000042277Danio rerio
 Efnb3ENSMUSG00000003934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNB2 / P52799 / ephrin B2ENSG0000012526640
EFNB1 / P98172 / ephrin B1ENSG0000009077639


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016198 axon choice point recognition IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity TAS
 molecular_functionGO:0046875 ephrin receptor binding IDA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000137575 SDCBP / O00560 / syndecan binding protein  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction / -
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / reaction / complex
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000169439 SDC2 / P34741 / syndecan 2  / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex / -
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction / -
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000214944 Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction / complex
 ENSG00000145715 RASA1 / P20936 / RAS p21 protein activator 1  / complex / reaction
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000205726 ITSN1 / Q15811 / intersectin 1  / reaction / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction






 

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