ENSG00000106299


Homo sapiens

Features
Gene ID: ENSG00000106299
  
Biological name :WASL
  
Synonyms : O00401 / WASL / Wiskott-Aldrich syndrome like
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.32
Gene start: 123681935
Gene end: 123749067
  
Corresponding Affymetrix probe sets: 205809_s_at (Human Genome U133 Plus 2.0 Array)   205810_s_at (Human Genome U133 Plus 2.0 Array)   224813_at (Human Genome U133 Plus 2.0 Array)   230340_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000223023
NCBI entrez gene - 8976     See in Manteia.
OMIM - 605056
RefSeq - NM_003941
RefSeq Peptide - NP_003932
swissprot - O00401
Ensembl - ENSG00000106299
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 waslaENSDARG00000014113Danio rerio
 waslbENSDARG00000006283Danio rerio
 ENSGALG00000037819Gallus gallus
 WASLENSGALG00000008797Gallus gallus
 WaslENSMUSG00000029684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WAS / P42768 / Wiskott-Aldrich syndromeENSG0000001528548


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR030214  Neural Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006900 vesicle budding from membrane ISS
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008154 actin polymerization or depolymerization TAS
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0016050 vesicle organization ISS
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030050 vesicle transport along actin filament ISS
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0034629 cellular protein-containing complex localization IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051653 spindle localization IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:1903526 negative regulation of membrane tubulation IDA
 biological_processGO:2000370 positive regulation of clathrin-dependent endocytosis ISS
 biological_processGO:2000402 negative regulation of lymphocyte migration IMP
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030478 actin cap IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030695 GTPase regulator activity TAS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
NOSTRIN mediated eNOS trafficking
Nephrin family interactions
EPHB-mediated forward signaling
DCC mediated attractive signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000183853 Q96J84 / KIRREL1 / kirre like nephrin family adhesion molecule 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000105974 CAV1 / Q03135 / caveolin 1  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000161270 NPHS1 / O60500 / NPHS1, nephrin  / reaction / complex
 ENSG00000122574 WIPF3 / A6NGB9 / WAS/WASL interacting protein family member 3  / reaction
 ENSG00000164867 NOS3 / P29474 / nitric oxide synthase 3  / reaction
 ENSG00000213672 Q9NZQ3 / NCKIPSD / NCK interacting protein with SH3 domain  / reaction
 ENSG00000115935 WIPF1 / O43516 / WAS/WASL interacting protein family member 1  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction
 ENSG00000163072 Q8IVI9 / NOSTRIN / nitric oxide synthase trafficking  / complex / reaction
 ENSG00000171475 WIPF2 / Q8TF74 / WAS/WASL interacting protein family member 2  / reaction
 ENSG00000205726 ITSN1 / Q15811 / intersectin 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr