ENSG00000164867


Homo sapiens

Features
Gene ID: ENSG00000164867
  
Biological name :NOS3
  
Synonyms : nitric oxide synthase 3 / NOS3 / P29474
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.1
Gene start: 150990995
Gene end: 151014588
  
Corresponding Affymetrix probe sets: 205581_s_at (Human Genome U133 Plus 2.0 Array)   229093_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420551
Ensembl peptide - ENSP00000417143
Ensembl peptide - ENSP00000418245
Ensembl peptide - ENSP00000420215
Ensembl peptide - ENSP00000297494
NCBI entrez gene - 4846     See in Manteia.
OMIM - 163729
RefSeq - XM_017012234
RefSeq - NM_000603
RefSeq - NM_001160109
RefSeq - NM_001160110
RefSeq - NM_001160111
RefSeq - XM_006716002
RefSeq - XM_017012232
RefSeq - XM_017012233
RefSeq Peptide - NP_000594
RefSeq Peptide - NP_001153582
RefSeq Peptide - NP_001153583
RefSeq Peptide - NP_001153581
swissprot - A0A0A0MTA6
swissprot - E7ESA7
swissprot - H7C4V4
swissprot - P29474
Ensembl - ENSG00000164867
  
Related genetic diseases (OMIM): 104300 - {Alzheimer disease, late-onset, susceptibility to}, 104300
  163729 - {Coronary artery spasm 1, susceptibility to}
  189800 - {Hypertension, pregnancy-induced}, 189800
  145500 - {Hypertension, susceptibility to}, 145500
  601367 - {Ischemic stroke, susceptibility to}, 601367
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Nos3ENSMUSG00000028978Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOS1 / P29475 / nitric oxide synthase 1ENSG0000008925058
NOS2 / P35228 / nitric oxide synthase 2ENSG0000000717148
POR / P16435 / cytochrome p450 oxidoreductaseENSG0000012794817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001974 blood vessel remodeling ISS
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0003057 regulation of the force of heart contraction by chemical signal IEA
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IMP
 biological_processGO:0006527 arginine catabolic process IDA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0007005 mitochondrion organization ISS
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0008217 regulation of blood pressure NAS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0009408 response to heat NAS
 biological_processGO:0010544 negative regulation of platelet activation NAS
 biological_processGO:0014740 negative regulation of muscle hyperplasia ISS
 biological_processGO:0014806 smooth muscle hyperplasia ISS
 biological_processGO:0019430 removal of superoxide radicals IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0034405 response to fluid shear stress IEP
 biological_processGO:0042311 vasodilation NAS
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045454 cell redox homeostasis TAS
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0050880 regulation of blood vessel size ISS
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:0051186 cofactor metabolic process TAS
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 molecular_functionGO:0003785 actin monomer binding IPI
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0034617 tetrahydrobiopterin binding IDA
 molecular_functionGO:0034618 arginine binding IDA
 molecular_functionGO:0046870 cadmium ion binding NAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding NAS
 molecular_functionGO:0050661 NADP binding NAS
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
NOSTRIN mediated eNOS trafficking
NOSIP mediated eNOS trafficking
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / reaction
 ENSG00000142546 NOSIP / Q9Y314 / nitric oxide synthase interacting protein  / reaction / complex
 ENSG00000163072 Q8IVI9 / NOSTRIN / nitric oxide synthase trafficking  / complex / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / complex / reaction
 ENSG00000105974 CAV1 / Q03135 / caveolin 1  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000164867 NOS3 / P29474 / nitric oxide synthase 3  / complex
 ENSG00000120992 LYPLA1 / O75608 / lysophospholipase I  / reaction
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / reaction / complex
 ENSG00000175893 Q8IVQ6 / ZDHHC21 / zinc finger DHHC-type containing 21  / reaction






 

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