ENSG00000089250


Homo sapiens

Features
Gene ID: ENSG00000089250
  
Biological name :NOS1
  
Synonyms : nitric oxide synthase 1 / NOS1 / P29475
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.22
Gene start: 117208142
Gene end: 117452170
  
Corresponding Affymetrix probe sets: 1560974_s_at (Human Genome U133 Plus 2.0 Array)   207309_at (Human Genome U133 Plus 2.0 Array)   207310_s_at (Human Genome U133 Plus 2.0 Array)   231916_at (Human Genome U133 Plus 2.0 Array)   239132_at (Human Genome U133 Plus 2.0 Array)   240911_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339862
Ensembl peptide - ENSP00000477999
Ensembl peptide - ENSP00000320758
Ensembl peptide - ENSP00000337459
NCBI entrez gene - 4842     See in Manteia.
OMIM - 163731
RefSeq - XM_017019347
RefSeq - NM_000620
RefSeq - NM_001204213
RefSeq - NM_001204214
RefSeq - NM_001204218
RefSeq - XM_011538398
RefSeq - XM_017019345
RefSeq - XM_017019346
RefSeq Peptide - NP_001191147
RefSeq Peptide - NP_000611
RefSeq Peptide - NP_001191142
RefSeq Peptide - NP_001191143
swissprot - P29475
swissprot - C9J5P6
swissprot - B3VK56
Ensembl - ENSG00000089250
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos1ENSDARG00000068910Danio rerio
 NOS1ENSGALG00000008177Gallus gallus
 Nos1ENSMUSG00000029361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOS3 / P29474 / nitric oxide synthase 3ENSG0000016486747
NOS2 / P35228 / nitric oxide synthase 2ENSG0000000717143
POR / P16435 / cytochrome p450 oxidoreductaseENSG0000012794814


Protein motifs (from Interpro)
Interpro ID Name
 IPR001094  Flavodoxin-like
 IPR001433  Oxidoreductase FAD/NAD(P)-binding
 IPR001478  PDZ domain
 IPR001709  Flavoprotein pyridine nucleotide cytochrome reductase
 IPR003097  FAD-binding, type 1
 IPR004030  Nitric oxide synthase, N-terminal
 IPR008254  Flavodoxin/nitric oxide synthase
 IPR012144  Nitric-oxide synthase, eukaryote
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029039  Flavoprotein-like superfamily
 IPR036034  PDZ superfamily
 IPR036119  Nitric oxide synthase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEP
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006527 arginine catabolic process IC
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IBA
 biological_processGO:0007520 myoblast fusion TAS
 biological_processGO:0009408 response to heat IDA
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol TAS
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IEA
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IBA
 biological_processGO:0033555 multicellular organismal response to stress IMP
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0042136 neurotransmitter biosynthetic process TAS
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0042738 exogenous drug catabolic process IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0045454 cell redox homeostasis TAS
 biological_processGO:0045776 negative regulation of blood pressure IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051346 negative regulation of hydrolase activity IEA
 biological_processGO:0051612 negative regulation of serotonin uptake IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction TAS
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity TAS
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0098735 positive regulation of the force of heart contraction IEA
 biological_processGO:0098924 retrograde trans-synaptic signaling by nitric oxide IEA
 biological_processGO:0140196 positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IEA
 biological_processGO:1902307 positive regulation of sodium ion transmembrane transport ISS
 biological_processGO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel TAS
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0001917 photoreceptor inner segment ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:1990425 ryanodine receptor complex TAS
 molecular_functionGO:0003958 NADPH-hemoprotein reductase activity IBA
 molecular_functionGO:0004517 nitric-oxide synthase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0010181 FMN binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity ISS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0034617 tetrahydrobiopterin binding NAS
 molecular_functionGO:0034618 arginine binding TAS
 molecular_functionGO:0044325 ion channel binding TAS
 molecular_functionGO:0046870 cadmium ion binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0097110 scaffold protein binding ISS


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0002571 Achalasia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000058668 ATP2B4 / P23634 / ATPase plasma membrane Ca2+ transporting 4  / reaction / complex






 

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